I TUOI DATI
I TUOI ORDINI
N. prodotti: 0
Totale ordine: € 0,00
I TUOI ABBONAMENTI
I TUOI ARTICOLI
Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899
International Angiology 2000 June;19(2):135-41
Microvascular blood is distributed more to venules than to arterioles in patients with Buerger’s disease. Observation of bulbar conjunctiva by intravital microscope system
Homma S. a,d, Tsushima N. c, Minamiyama M. b, Hayashi T. a, Matsuo H. a
From the a Department of Internal Medicine, b Department of Vascular Physiology, National Cardiovascular Center, Suita, c Tsushima Clinic, Toyonaka,
d Department of Critical Care Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
Background. It has been a matter of controversy whether abnormalities of organs other than extremities may be a clinical manifestation of Buerger’s disease (thromboangiitis obliterans; TAO). In the present investigation, our aim was to quantitatively characterise the configuration of microvascular networks in bulbar conjunctiva, which is not affected apparently, in patients with thromboangiitis obliterans.
Methods. Nine men with thromboangiitis obliterans attended our hospital and nine male volunteers as normal controls were enrolled in the study. We observed and analysed the configuration of the network of a bulbar conjunctiva by use of intravital microscope system with computer assisted image processing functions. Microvessel density was described in terms of the sum of vessel length in a ROI and tortuosity was evaluated according to the ratio of vessel length to the direct distance between the two terminals.
Results. In the microcirculation of bulbar conjunctiva in thromboangiitis obliterans, arteriole diameter was significantly decreased and density of venules was significantly increased. Increased venular density was due in part to increased tortuosity of venules.
Conclusions. Consequently, microvascular blood was distributed more to venules than to arterioles in patients with thromboangiitis obliterans. Venule/arteriole ratios of diameter, tortuosity and microvessel density may be useful parameters to characterize the configuration of microvascular networks in thromboangiitis obliterans.