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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 2000 March;19(1):14-17

lingua: Inglese

Treadmill exercise-induced release of endothelin-1 in patients with peripheral arterial occlusive disease at Fontaine stage IIb

Mangiafico R. A., Malatino L. S., Spada R. S., Santonocito M., Messina R., Dell’Arte S., Attinà T.

From the Insti­tute of Clin­i­ca Med­i­ca “L. Con­do­rel­li”, Uni­ver­sity of Cata­nia, Cata­nia, Italy


Back­ground. Endo­the­lin-1 (ET-1) is an endo­the­lial vas­o­con­stric­tor mit­o­gen­ic pep­tide which is ­thought to be a mark­er of endo­the­lial dam­age and a poten­tial par­tic­i­pant in the path­o­phy­sio­log­i­cal pro­cess­es of the devel­op­ment of ath­e­ros­cle­rot­ic ­lesions and dis­ease ­states asso­ciat­ed with vaso­con­stric­tion and vasos­pasm.
Meth­ods. To inves­ti­gate the endo­the­lin-1 ­release in ­response to dynam­ic exer­cise in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease (PAOD), plas­ma con­cen­tra­tions were deter­mined by radio­im­mu­noas­say in 16 ­patients (14 men, 2 women, mean age 56.2±8.1 years) with periph­er­al arte­ri­al occlu­sive dis­ease at Fon­taine stage IIb and in 10 con­trol sub­jects (8 men, 2 women, mean age 58.1±7.2 years) in nor­mal ­health dur­ing tread­mill test­ing (slope 5%, speed 3 km/hr). Blood sam­ples were col­lect­ed at rest from an ante­cu­bi­tal vein, at the onset of claud­i­ca­tion pain, and 10 min­utes after exer­cise.
­Results. Mean plas­ma endo­the­lin-1 con­cen­tra­tions dur­ing the ­stress test ­increased sig­nif­i­cant­ly in the ­patients with arte­ri­al dis­ease, ris­ing from basal val­ues of 4.4±0.6 pmol/L to val­ues of 8.9±0.7 pmol/L at the end of the test (p<0.0001), where­as it did not ­change sig­nif­i­cant­ly in con­trol sub­jects (ris­ing from 2.6±0.4 pmol/L to 2.7±0.5 pmol/L). Fur­ther, plas­ma endo­the­lin-1 in the ­patients with arte­ri­al dis­ease was at all times high­er than in the con­trol sub­jects (p<0.0001).
Con­clu­sions. In con­clu­sion, this study shows that in ­patients with periph­er­al arte­ri­al occlu­sive dis­ease, plas­ma endo­the­lin-1 increas­es after tread­mill exer­cise per­formed until claud­i­ca­tion pain super­venes. ­Raised endo­the­lin-1 could be a mark­er of ischaem­ic acute endo­the­lial dam­age and/or could con­trib­ute to ­increase the vas­cu­lar resis­tance in ischae­mic limbs of these ­patients dur­ing dynam­ic exer­cise by pro­mot­ing arte­ri­al/arter­i­o­lar vaso­con­stric­tion or vasos­pasm.

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