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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2000 March;19(1):14-17
Treadmill exercise-induced release of endothelin-1 in patients with peripheral arterial occlusive disease at Fontaine stage IIb
Mangiafico R. A., Malatino L. S., Spada R. S., Santonocito M., Messina R., Dell’Arte S., Attinà T.
From the Institute of Clinica Medica “L. Condorelli”, University of Catania, Catania, Italy
Background. Endothelin-1 (ET-1) is an endothelial vasoconstrictor mitogenic peptide which is thought to be a marker of endothelial damage and a potential participant in the pathophysiological processes of the development of atherosclerotic lesions and disease states associated with vasoconstriction and vasospasm.
Methods. To investigate the endothelin-1 release in response to dynamic exercise in patients with peripheral arterial occlusive disease (PAOD), plasma concentrations were determined by radioimmunoassay in 16 patients (14 men, 2 women, mean age 56.2±8.1 years) with peripheral arterial occlusive disease at Fontaine stage IIb and in 10 control subjects (8 men, 2 women, mean age 58.1±7.2 years) in normal health during treadmill testing (slope 5%, speed 3 km/hr). Blood samples were collected at rest from an antecubital vein, at the onset of claudication pain, and 10 minutes after exercise.
Results. Mean plasma endothelin-1 concentrations during the stress test increased significantly in the patients with arterial disease, rising from basal values of 4.4±0.6 pmol/L to values of 8.9±0.7 pmol/L at the end of the test (p<0.0001), whereas it did not change significantly in control subjects (rising from 2.6±0.4 pmol/L to 2.7±0.5 pmol/L). Further, plasma endothelin-1 in the patients with arterial disease was at all times higher than in the control subjects (p<0.0001).
Conclusions. In conclusion, this study shows that in patients with peripheral arterial occlusive disease, plasma endothelin-1 increases after treadmill exercise performed until claudication pain supervenes. Raised endothelin-1 could be a marker of ischaemic acute endothelial damage and/or could contribute to increase the vascular resistance in ischaemic limbs of these patients during dynamic exercise by promoting arterial/arteriolar vasoconstriction or vasospasm.