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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1999 December;18(4):327-30

lingua: Inglese

Ther­a­peu­tic effi­ca­cy of flav­o­noids in oede­ma fol­low­ing reper­fu­sion on acute­ly ischaem­ic legs

Filis K. A., Georgo­pou­los S. E., Papas S. C., Vot­teas V., Bas­tou­nis E. A.

From the First Depart­ment of Sur­gery, Uni­ver­sity of Ath­ens Med­i­cal ­School, Ath­ens, ­Greece


Back­ground. The aim of this study was to inves­ti­gate the ­effect of a pur­i­fied, micro­nised, flav­o­noid frac­tion (Daf­lon) in lower limb oede­ma devel­oped after ­delayed embo­lec­to­my and suc­cess­ful reper­fu­sion of acute­ly ischaem­ic legs.
Meth­ods. Our ­series con­sist­ed of 19 ­patients with pro­longed, acute ischae­mia of the lower extrem­ity ­caused by arte­ri­al embo­lism, who had under­gone suc­cess­ful embo­lec­to­my. ­Patients were ran­dom­ised into two ­groups; ten ­patients (group I) treat­ed with flav­o­noids, were com­pared to nine given a pla­ce­bo. Ankle and calf cir­cum­fer­enc­es, ­venous capac­i­tance and ­venous emp­ty­ing time were meas­ured pre­op­er­a­tive­ly [T1], on the 2nd [T2], 5th [T3], 8th [T4] and 30th [T5] post­op­er­a­tive days.
­Results. An ­increase of ankle and calf cir­cum­fer­ence up to 9% and 13.5% respec­tive­ly, as com­pared with pre­op­er­a­tive val­ues was dem­on­strat­ed. There was a reduc­tion in oede­ma for­ma­tion in ­patients with the Daf­lon group, which ­reached sta­tis­ti­cal sig­nif­i­cance only in the ­ankles (p=0.0276). Calf dif­fer­enc­es were sta­tis­ti­cal­ly sig­nif­i­cant on the sec­ond and fifth post­op­er­a­tive days (p<0.05). ­Venous hae­mod­y­nam­ics were con­sid­er­ably ­improved by Daf­lon (p<0.001).
Con­clu­sions. Daf­lon 500 mg had an inhib­i­to­ry ­effect on mod­er­ate oede­ma devel­oped after revas­cu­lar­isa­tion of an ischaem­ic limb.

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