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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1999 September;18(3):193-7

lingua: Inglese

Cyto­kine pat­terns and the ­effects of a pre­op­er­a­tive ster­oid treat­ment in the ­patients with abdom­i­nal aor­tic aneu­rysms

Komo­ri K., Ish­i­da M., Mat­su­mo­to T., Kume M., Ohta S., Takeu­chi K., Ono­ha­ra T., Sugim­a­chi K.

From the Sec­ond Depart­ment of Sur­gery, Facul­ty of Med­i­cine, Kyu­shu Uni­ver­sity, Fukuo­ka, Japan


Back­ground. The aim of this study was to inves­ti­gate the cyto­kine pat­terns of ­patients with abdom­i­nal aor­tic aneu­rysms and the ­effects of pre­op­er­a­tive ster­oid admin­is­tra­tion on sur­gi­cal ­stress.
Meth­ods. From Jan­u­ary 1996 to ­August 1996, 20 con­sec­u­tive ­patients under­went an elec­tive recon­struc­tion of infra­ren­al abdom­i­nal aor­tic aneu­rysms. The ­patients were ran­dom­ly divid­ed into two ­groups con­sist­ing of a con­trol group (n=10) and a ster­oid group (n=10), in whom 1 g of meth­yl­pred­nis­o­lone was intra­ve­nous­ly admin­is­tered two hours ­before the oper­a­tion. Meas­ures. Inter­leu­kin-6 was seri­al­ly meas­ured and the per­i­op­er­a­tive param­e­ters includ­ing C-reac­tive pro­tein were com­pared ­between both the con­trol and the ster­oid ­groups.
­Results. The inter­leu­kin-6 val­ues in the ster­oid group imme­di­ate­ly after declamp­ing, as well as at one and three post­op­er­a­tive days were sig­nif­i­cant­ly lower than those in the con­trol group. C-reac­tive pro­tein val­ues at one post­op­er­a­tive day in the ster­oid group were also sig­nif­i­cant­ly lower than those in the con­trol group. In one ­patient with a rup­tured abdom­i­nal aor­tic aneu­rysm, the inter­leu­kin-6 val­ues were high­er than those in the ­patients under­go­ing elec­tive sur­gery through­out the study.
Con­clu­sions. These ­results thus sug­gest that pre­op­er­a­tive ster­oid admin­is­tra­tion using meth­yl­pred­nis­o­lone in ­patients with abdom­i­nal aor­tic aneu­rysms ­appears to ­reduce sur­gi­cal ­stress by decreas­ing cyto­kine ­release.

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