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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 1999 June;18(2):140-4
Neutrophil count and amputation in critical limb ischaemia
Belch J. J. F. *, Sohngen O. * **, Robb R. *, Voleske P. * **, Sohngen W. * **
From the Section of Vascular Medicine, University Department of Medicine, Ninewells Hospital, Dundee, Scotland
** Research Center, Gruenenthal GmbH, Aachen, Germany
Background. The white blood cell count (WCC) is known to be predictive of cardiac and cerebral vascular events. No one has yet investigated this in critical limb ischaemia (CLI).
Methods. Baseline WCC was examined in relation to lower limb amputation 6 months after a 4 week treatment period with i.v. placebo or i.v. taprostene in 366 patients with CLI.
Results. The WCC was related to a significant increase in amputation, relative risk 1.6 (p=0.001, 95% CI: 1.2-2.0) in CLI patients with WCC≥9×109/l vs patients with WCC <9×109/l. Its association with disabling amputation persisted on logistic regression analyses which included cigarette smoking as a variable and also treatment group (p<0.001). The WCC is therefore an easily measurable prognostic variable in CLI.
Conclusions. The white blood cell may promote intractable tissue ischaemia by capillary plugging and/or release of toxic chemicals and may have distinct effects on tissue viability.