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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,899

Periodicità: Bimestrale

ISSN 0392-9590

Online ISSN 1827-1839


International Angiology 1998 Giugno;17(2):89-92


Restricted usage of T-cell recep­tor Vα-Vβ genes in infil­trat­ing cells in the aor­tic tis­sue of a ­patient with ath­e­ros­cle­rot­ic aor­tic aneu­rysm

Seko Y. * °° **, Takahashi N. *, Sato O. °, Takagi A. °, Yagita H. °°, Okumura K. °°, Yazaki Y. **

From the * Third Department of Internal Medicine, and ° Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo,
°° Department of Immunology, School of Medicine, Juntendo Uni­ver­sity, Tokyo, and ** Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan

We ­report a rare case of an ath­e­ros­cle­rot­ic aor­tic aneu­rysm with lym­pho­cyte infil­tra­tion in which T-cell recep­tor (TCR) Vα as well as Vβ gene usage was restrict­ed. Immunohistochemical stud­ies ­showed that the infil­trat­ing cells main­ly con­sist­ed of mac­ro­phag­es, nat­u­ral kill­er (NK) cells, cyto­tox­ic T lym­pho­cytes (CTLs) and T-help­er (Th) cells, and that there were ­almost no infil­trat­ing δ T lym­pho­cytes, and human leu­ko­cyte anti­gen (HLA) class I and 65-kD heat-shock pro­tein (HSP-65) was not strong­ly ­expressed in the aor­tic tis­sue. Although the immu­no­his­to­chem­i­cal data were con­sis­tent with an ordi­nary ath­e­ros­cle­rot­ic aor­tic aneu­rysm, in which TCR Vα-Vβ gene usage is known to be poly­clo­nal, the restrict­ed TCR gene usage sug­gests that a cer­tain auto­im­mune mech­a­nism was ­involved in the path­o­gen­e­sis of this case sim­i­lar to Takayasu’s arter­itis, in which mas­sive infil­tra­tion of δ T lym­pho­cytes and ­strong expres­sion of HSP-65 in the aor­tic tis­sue are char­ac­ter­is­tic.

lingua: Inglese


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