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Rivista di Angiologia
Official Journal of the , the International Union of Phlebology and the
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 1998 March;17(1):49-52
Levels of the inhibitor of PMN-Elastase in venous blood reflowing from chronically affected veins: the role of venous stasis
Signorelli S. *, Arpaia G., Cimminiello C., Pennisi G. *, Borsetto M. **, Mazzullo M. ***, Bonfardeci C., Andreozzi G. M. *
From the Vascular and Thrombotic Pathology, II Medical Department, S. Carlo Borromeo Hospital, Milan, Italy
* Department of Internal Medicine “A. Francaviglia” Chair of Angiology, University of Catania, Italy
** Vascular Surgery Department, S. Donato Hospital, Italy
*** Department of Internal Medicine, Hospital of Lecco, Italy.
Background. Attention has recently been paid to the cell and biochemical disorders involved in chronic venous insufficiency (CVI) and to their possible relationship to the endothelium.
Methods. In the present study, carried out in 14 patients with CVI, we evaluated the levels of the inhibitor of elastase (I-EL) generated by polymorphonucleate cells in the blood reflowing from affected superficial veins of legs both at rest and after prolonged venous stasis (1 hour in standing position).
Results. We evaluated the I-EL both as percentage of activity (baseline 82.3±24.5%; after stasis 100.7±37.8%) and as absolute values (0.67±0.26 U/ml; after stasis 0.79± 0.39 U/ml). In blood samples taken after venous stasis we found a tendency toward a trapping of white blood cells and an increase of the haematocrit over baseline. The difference in the percentages of activity of I-EL was statistically significant, but only a trend was observed for the absolute values.
Conclusions. We believe that the typical haemodynamic disorders of patient with CVI increased by prolonged venous stasis can modify the function of white blood cells, which are closely linked with venous hypertension, thus playing an important role in the pathogenesis of skin ulcers.