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Rivista di Angiologia

Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
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International Angiology 1998 March;17(1):15-21


lingua: Inglese

Carotid ath­ero­scler­o­sis in sub­jects with dif­fer­ent hyper­lip­i­dae­mia phe­no­types

Irace C., Pujia A., Motti C. *, Mas­si­mo F., Gnas­so A.

From the University of Catanzaro, Department of Clinical and Experimental Medicine, Atherosclerosis Centre, Catanzaro, Italy
* Department of Internal Medicine, “Tor Vergata” University, Rome, Italy


Objective. To eval­u­ate the pres­ence of carot­id ­plaque and/or sten­o­sis in ­patients with dif­fer­ent phe­no­type of hyper­lip­i­dae­mia.
Experimental ­design. Case-con­trol study.
Setting. Outpatients meta­bol­ic clin­ic.
Patients. Sixty type IIa, 50 type IIb and 40 type IV hyper­lip­i­daem­ic sub­jects were com­pared with 50 nor­mo­lip­i­daem­ic con­trols, ­matched for sex and age.
Interventions. Blood lipid anal­y­sis for phe­no­type clas­sifi­ca­tion was per­formed after two ­months of diet. Blood pres­sure was meas­ured by a zero-ran­dom sphyg­mom­a­nom­e­ter. CHD risk fac­tors, smok­ing habit, pre­vi­ous and ongo­ing drug ther­a­py were ­assessed by a self-admin­is­tered ques­tion­naire. Echo-Doppler exam­ina­tion of the extra­cra­ni­al arter­ies (com­mon, internal and exter­nal carot­id ­artery and bulb) was done by a Multigon Angioview 600 pro­vid­ed with a 7.5 MHz probe for B-mode and 5 MHz for ­pulsed Doppler. Subjects were clas­si­fied as hav­ing carot­id ath­ero­scler­o­sis when a ­plaque and/or a sten­o­sis was found in at least one of the exam­ined seg­ments and as nor­mal when no ath­e­ros­cle­rot­ic ­lesions were detect­ed.
Results. There were more hyper­ten­sives among type IV sub­jects where­as the prev­a­lence of smok­ers and dia­bet­ics was sim­i­lar in all four ­groups. The prev­a­lence of carot­id ath­ero­scler­o­sis was high­er in type IIb and IIa sub­jects than in con­trols (58% and 38% respec­tive­ly vs 14%, p<0.01) while in type IV sub­jects it was com­par­able to that of con­trols (25%).
Conclusions. The ­present find­ings show that hyper­cho­les­ter­o­lae­mia and mixed hyper­lip­i­dae­mia are fre­quent­ly asso­ciat­ed with carot­id ath­ero­scler­o­sis, where­as hyper­trig­ly­cer­i­dae­mia is not. The role of hyper­trig­ly­cer­i­dae­mia in the devel­op­ment of ath­ero­scler­o­sis seems medi­at­ed by mech­a­nisms other than ­plaque for­ma­tion.

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