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Rivista di Medicina Interna e Farmacologia


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 January-February;176(1-2):71-4

DOI: 10.23736/S0393-3660.16.03300-3

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Heparin-binding EGF-like growth factor in diagnosis of malignant phyllodes tumor of the breast: a case report

Giuseppe MUSUMECI 1, Francesca M. TROVATO 2, Marta A. SZYCHLINSKA 1, Soraya SCUDERI 1, Federica FIDONE 2, Rosa IMBESI 1, Paola CASTROGIOVANNI 1

1 Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy; 2 Department of Clinical and Experimental Medicine, Internal Medicine Division, School of Medicine, University of Catania, Catania, Italy


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Phyllodes tumors (PT) of the breast are rare fibroephitelial neoplasms. Malignant phyllodes tumor (MPT) usually presents rapid growth and it is difficult to distinguish it from a pure sarcoma. We report a rare case of diagnosed MPT in which we performed immunohistochemistry (IHC) for heparin-binding EGF-like growth factor (HB-EGF) considering that HB-EGF IHC was already used in other studies as a possible target of cancer in other pathologies. A 43-year-old patient presented, at physical examination, a palpable mass on the left breast with accentuated vascularization and increased growth in the last four months. The diagnosis was made through various examination such as mammogram, breast ultrasound, color-Doppler, PET, histopathological analysis and the HB-EGF IHC. Macroscopy evidenced a trilobulated lesion, measuring 9x7x7cm, and the anatomopathologic analysis confirmed the diagnosis of MPT. A strong cytoplasmic HB-EGF immunolabeling was evident. IHC is a very specific technique often able to differentiate such tumors. In the present case report IHC has evidenced the expression of HB-EGF, suggesting further investigation in order to consider HB-EGF as a possible marker in the diagnosis of MPT.


KEY WORDS: Phyllodes tumor - Breast - Immunohistochemistry - Histology - Heparin-binding EGF-like growth factor

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Publication History

Issue published online: November 21, 2016
Manuscript accepted: March 2, 2016
Manuscript received: November 21, 2015

Per citare questo articolo

Musumeci G, Trovato FM, Szychlinska MA, Scuderi S, Fidone F, Imbesi R. Heparin-binding EGF-like growth factor in diagnosis of malignant phyllodes tumor of the breast: a case report. Gazz Med Ital - Arch Sci Med 2017;176:71-4. DOI: 10.23736/S0393-3660.16.03300-3

Corresponding author e-mail

g.musumeci@unict.it