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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2016 Giugno;175(6):270-5

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Exercise training and systemic inflammation in infarcted patients: a systematic review

Catarina DE ANDRADE BARBOZA 1, Juliana C. MARTINS FREITAS DE OLIVEIRA 1, Kátia BILHAR SCAPINI 2, Luiza M. SILVA 1, Maria L. DE JESUS MIRANDA 1, Bruno RODRIGUES 3

1 Human Movement Laboratory, Universidade São Judas Tadeu (USJT), São Paulo, Brazil; 2 Hypertension Unit, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; 3 Faculty of Physical Education, Universidade Estadual de Campinas, Campinas, SP, Brazil


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INTRODUCTION: The role of exercise training in the prevention and management of cardiovascular diseases and post infarction patients is becoming increasingly important, particularly in the modulation of different risk factors, including the immune system. However, the effects of exercise on immune function in these patients need further clarification. Our goal was to systematically review changes in immune parameters following chronic exercise in the post infarction patients of randomized controlled clinical trials (RCTs).
DATA ACQUISITION: MEDLINE, Cochrane-CENTRAL and LILACS databases were searched from 1979 through 2014 by two independent reviewers. Of the 651 retrieved articles, five met the inclusion criteria.
DATA SYNTHESIS: The selected RCTs protocols ranged from three to 24 weeks of exercise training, and evaluated cardiorespiratory capacity and inflammation markers in relation to the control group. The training effect on inflammatory profile was examined in the 5 studies. Following exercise, decreases were seen in the C-reactive protein, and pro and anti-inflammatory mediators remained stable.
CONCLUSIONS: In conclusion, exercise training programs focusing on aerobic training, carried out for more than 90 minutes per week are associated with decreased CRP and improved inflammatory profile in patients after an ischemic event.

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