Ricerca avanzata

Home > Riviste > Gazzetta Medica Italiana Archivio per le Scienze Mediche > Fascicoli precedenti > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2014 Dicembre;173(12) > Gazzetta Medica Italiana Archivio per le Scienze Mediche 2014 Dicembre;173(12):611-9



Rivista di Medicina Interna e Farmacologia

Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index

Periodicità: Mensile

ISSN 0393-3660

Online ISSN 1827-1812


Gazzetta Medica Italiana Archivio per le Scienze Mediche 2014 Dicembre;173(12):611-9


Seasonal variations in foot gangrene and extremity amputations

Has B. 1, 2, Lehner V. 1, Čandrlić K. 1, Pinotić K. 1, Ištvanić T. 1, Flam D. 1, Kovač D. 1, Has-Schön E. 3

1 Department of Surgery, Clinical Hospital Osijek, Osijek, Croatia;
2 J.J. Strossmayer University, Medical Faculty, Osijek, Croatia;
3 J.J. Strossmayer University, Department of Biology, Osijek, Croatia

AIM: The aim of our study was to investigate the influence of PTH and vitamin D periodical changes, on extremity amputation incidence due to gangrene development.
METHODS: This study includes 1439 elderly patients, 224 with (KD) and 1215 without (noKD group) accompanying kidney disease, amputated at the Surgical Department of the Clinical Hospital in Osijek, Croatia, in the nine years period. Total number of amputations was correlated with number of sunny hours in the each month of the analyzed period. Comparisons of mean amputation frequency were also performed between selected month(s).
RESULTS: Almost all performed amputations had to be done on lower extremities. The level of amputation differed between groups: in KD group there were more leg (upper and lower part), and in noKD group more leg finger amputations. A significant negative correlation between winter and summer (without July) months was recorded for KD group, while no such correlation could be shown for noKD group, were slightly higher number of amputations were found in summer compared to winter months.
CONCLUSION: In both patient groups, PTH activity is crucial for gangrene development. In KD patients, higher PTH activity and low vitamin D quantities might cause greater incidence of amputation in winter months. In noKD patients, a facilitated PTH activity in combination with high vitamin D quantities might cause high frequency of gangrene incidence also in summer months. In addition, it is evident that kidney disease contributes to severity of gangrene development, demanding higher levels of amputation.

lingua: Inglese


inizio pagina