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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
Rivista di Medicina Interna e Farmacologia
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2014 June;173(6):349-58
The influences of uVNTR polymorphism in the monoamine oxidase A gene on physiological and psychological factors in kumdo players
Lee J. K. 1, 2, Jung D. K. 1, Kim H. 3, Kim H. N. 4, Park Y. H. 5, Kang B. Y. 6
1 Department of Leisure and Sports, Sahmyook University, Seoul, Korea;
2 Fitness and Medicine Research Institute, Sahmyook University, Seoul, Korea;
3 Department of Health Promotion and Exercise, Daegu University, Kyungsan‑City, Korea;
4 School of Continuing Education, Daejin University, Gyunggi‑do, Korea;
5 College of Sport Science, Sungkyunkwan University, Gyeonggi‑do, Korea;
6 Department of Physical Education, Hanyang University, Seoul, Korea
AIM: The purpose of this study was to investigate the influences of the uVNTR polymorphism in the monoamine oxidase A (MAOA) gene on physiological and psychological factors of male kumdo players.
METHODS: A total of 66 kumdo players were recruited for this study, and divided into non-elite and elite players. Total genomic DNA was isolated from peripheral blood of participants, and the uVNTR polymorphism in the MAOA gene was analyzed using a PCR-direct detection method.
RESULTS: When two groups of kumdo players were compared, the mean values of left grip for elite kumdo players (44.2±7.5 kg) were significantly higher those of non-elite players (39.3±7.2 kg) (P<0.05). In addition, the uVNTR polymorphism in the MAOA gene may contribute to the inter-individual difference of blood lipoprotein(a) (Lp(a)) level in kumdo players (P<0.05). In particular, blood Lp(a) level of participants with the 4R allele (11.2±11.7 mg/dL) was significantly higher compared to those with the 3R allele (6.6±6.3 mg/dL).
CONCLUSION: Data from our study suggest that the uVNTR polymorphism in the MAOA gene may be a useful genetic marker influencing the inter-individual difference of blood Lp(a) level of kumdo players. Conduct of further studies using a larger sample size will be required in order to clarify the precise mechanism behind this association.