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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
Rivista di Medicina Interna e Farmacologia
Indexed/Abstracted in: BIOSIS Previews, EMBASE, Scopus, Emerging Sources Citation Index
Gazzetta Medica Italiana Archivio per le Scienze Mediche 2009 October;168(5):273-81
Gli effetti dell’allenamento sui ratti ipertesi
Wang S. 1,2, Fu F. H. 2, Zhu H. 3
1 Sports College, Guizhou Normal University, Guiyang, China
2 Hong Kong Baptist University, Hong Kong, China
3 Department of Sports, Shenzhen University, Shenzhen, China
Aim. The present study tested the hypothesis that plasticity of gabaergic nerves and glutamatergic nerves within ventrolateral medulla area contributed to exercise-induced change of autonomic balance of cardiovascular system in hypertensive individuals.
Methods. Thirty male spontaneous hypertensive rats (SHR) were assigned into trained (T) and untrained (UT) groups. The T group performed swimming exercise for a period of 8 weeks with moderate exercise intensity. Heart rate variability (HRV), epinephrine (E), norepinephrine (NE), and acetylcholine (ACH) in different organs (plasma and cardiac muscle) were measured after 8 weeks. The levels of GABA and Glu in RVLM were analyzed through micro-dialysis and high performance liquid chromatography.
Results. The results showed that chromic aerobic exercise could suppress the hypertensive state in hypertensive rats. The blunted hypertensive increase in resting arterial blood pressure was accompanied by an increased GABA level in RVLM, decreased NE in plasma and myocardium, increased ACH in myocardium, and a changed HRV (increased HF and HFnorm, decreased LFnorm and LF/HF).
Conclusion. These results suggested chronic aerobic exercise could change the autonomic balance of cardiovascular system in hypertensive individuals, which was closely related to plasticity of gabaergic nerves in the ventrolateral medulla area.