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Minerva Gastroenterologica e Dietologica 2016 Dec 01


lingua: Inglese

The curative effect of early use of enteral immunonutrition in postoperative gastric cancer: a meta-analysis

Hu QIANG 1, Lu HANG 1, Sun Y. SHUI 2

1 The Second Clinical Medical College of Zhejiang Chinese Medicine University, Hang Zhou, China; 2 Department of General Surgery, Tongde Hospital of Zhejiang Province, Hang Zhou, China


INTRODUCTION: It’s uncertain about the clinical efficacy which early enteral immunonutrition in postoperative gastric cancer patients,and this study attempts to assess its clinical efficacy.
EVIDENCE ACQUISITION: Use the search engine database incuding the Pubmed,the Cochrane library, Web of Science, Medline,and Embase,which there are comparative studies of early efficacy of enteral immune nutrition and standard enteral nutrition after gastric cancer operation.According to the studies,we use the RevMan 5.3 software to meta-analyse on the CD4 ,CD8, CD4/CD8, length of hospitalization, postoperative complications, and postoperative weight loss.
EVIDENCE SYNTHESIS: A total of 6 randomized control articles were included in this study,and it comprises 606 patients meta analysed. Among them, there were 308 cases of early postoperative enteral nutrition in patients with gastric cancer, and 298 cases were in standard enteral nutrition. Early postoperative enteral immune nutrition on seventh day of the CD4,CD8, and CD4/CD8 value greatly compared with standard enteral nutrition ,CD4(WMD = 2.71, CI: 2.71 ~ 7.79, P < 0.01), CD8 (WMD = 2.71, CI: 2.71 ~ 7.79, P < 0.01), CD4 / CD8 (WMD = 0.29, CI: 0.29 ~ 0.65, P < 0.01).Postoperative complications occurred in patients with gastric cancer after operation(OR = 0.46, CI 0.46 to 0.46, P < 0.01), the postoperative weight loss(WMD = 1.00, CI 1.00 to 2.82, P < 0.01), Length of hospitalization, and the value of early postoperative enteral immune nutrition group were lower than the early standard enteral nutrition.
CONCLUSIONS: It’s worth spreading the treatment which could improve the clinical efficacy of patients.

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