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Minerva Gastroenterologica e Dietologica 2015 Oct 22


lingua: Inglese

Hand ‘stress’ arthritis in young subjects: effects of Flexiqule (pharma-standard Boswellia extract). A preliminary case report

Belcaro G., Feragalli B., Cornelli U., Dugall M.

Irvine3 Labs, Dip Sc Med Or Biotec, Ch-Pe University


This case report (supplement registry study) evaluated subjects with painful ‘stress’ arthritis of the hand mainly localized at the joints. The patients received a suggestion to follow a rehabilitation plan (standard management; SM). A second group also used the same SM in association with the oral, pharma-standard supplement FlexiQule (Alchem) a new standardized, phytosomal preparation manufactured from the Boswellia plant, which can be used for self-management in inflammatory conditions (150 mg / 3 times daily). The two resulting registry groups included 12 subjects using SM+Flexiqule and and 11 controls (SM only). The groups were comparable. Serology showed no significant alterations: only ESR was slightly elevated (minimal elevation). After 2 weeks, the ESR was normal in the supplement group and mildly elevated in controls (p<0.05%). The decrease in hypertermic areas was greater/faster (p<0.05) in the supplement group. The identification of a working stress and the localization to the dominant hand was comparable in both groups. At 2 weeks, the decrease in pain was significantly faster and more important with the supplement (p<0.05). The hand became more usable in time and the score was better with the supplement (p<0.05). No supplemented patient had to use other drugs, while in the control group 3 subjects eventually used NSAIDs to control pain and stiffness and one used corticosteroids. In conclusion, the natural extract Flexiqule was effective in controlling work-related stress arthritis (without inflammaìtory signs) over a 2 weeks period, better than only Standard Management. More prolonged and larger studies are needed.

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Belcaro G, Feragalli B, Cornelli U, Dugall M. Hand ‘stress’ arthritis in young subjects: effects of Flexiqule (pharma-standard Boswellia extract). A preliminary case report. Minerva Gastroenterol Dietol 2015 Oct 22. 

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