N. prodotti: 0
Totale ordine: € 0,00
Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1642
OVERLAPPING GASTROINTESTINAL DISORDERS IN INFLAMMATORY BOWEL DISEASES
Fort Gasia M., Ghosh S., Iacucci M.
Division of Gastroenterology, University of Calgary, Alberta, Canada
AIM: Patients with long-standing inflammatory bowel disease (IBD) have higher risk for developing dysplasia and colorectal cancer and consequently surveillance colonoscopy is required. The colonic lesion in these patients are often flat and subtle and may be difficult to detect by white light standard endoscopy. We aimed to review the potential of novel electronic optical enhancement techniques to enhance endoscopic diagnosis and therapeutic management of dysplasia in IBD and emerging strategies that may be useful.
METHODS: We identified eligible and appropriate articles by electronic search of PubMed, MEDLINE and EMBASE between January 1980 and June 2015 using key words: dysplasia, colorectal cancer and IBD, surveillance in IBD, novel endoscopic techniques in IBD, therapeutic endoscopy in IBD, endoscopic mucosal resection, endoscopic submucosal dissection, pseudopolyps, dysplasia associated lesion or mass, adenoma associated lesion or mass, chromoendoscopy, autofluorescence, virtual chromoendoscopy, confocal endomicroscopy.
RESULTS: Segmental random biopsies during white-light colonoscopy have been the recommended strategy for many years. Chromoendoscopy with colonic dye spray has been gradually implemented in recent years in order to highlight abnormalities in the mucosa and target biopsies. Simultaneously, a new generation of high-definition endoscopes with electronic filter technology that provide a detailed assessment of the mucosal and vascular colonic pattern havebeen developed and these have been adopted in clinical practise. Furthermore, the introduction of confocal laser endomicroscopy (CLE) offers the possibility to assess and characterize lesions in real-time histology and it can predict dysplastic changes with high accuracy. With the evolving novel techniques and fresh evidence, modification of the current surveillance guidelines were required. Therefore, the SCENIC consensus guidelines have been recently published and have defined the best endoscopic techniques to detect and characterize dysplasia and the clinical implications and management of dysplasia in IBD patients.
CONCLUSION: Many uncertainties still remain whetherdye chromoendoscopy with targeted biopsies will be established as standard practice. However, optical enhancement endoscopic techniques are promising to perform surveillance colonoscopy with targeted biopsies for better assessment and management of the dysplastic lesions in IBD. Further studies are required to determine the best strategy for the diagnosis and treatment of dysplasia in IBD patients.