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EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE

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Official Journal of the Italian Society of Physical and Rehabilitation Medicine (SIMFER), European Society of Physical and Rehabilitation Medicine (ESPRM), European Union of Medical Specialists - Physical and Rehabilitation Medicine Section (UEMS-PRM), Mediterranean Forum of Physical and Rehabilitation Medicine (MFPRM), Hellenic Society of Physical and Rehabilitation Medicine (EEFIAP)
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European Journal of Physical and Rehabilitation Medicine 2017 Mar 13

DOI: 10.23736/S1973-9087.17.04452-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Disruption in bone marrow fat may attenuate testosterone action on muscle size after spinal cord injury. A case report

Ashraf S. GORGEY 1, 2 , Pamela D. MOORE 1, Rodney C. WADE 1, Ranjodh S. GILL 4, 5, Timothy LAVIS 1, 2, Robert A. ADLER 4, 5

1 Spinal Cord Injury Service and Disorders, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA; 2 Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA; 3 Radiology Service, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA; 4 Endocrinology Service, Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA; 5 Endocrine Division, Virginia Commonwealth University School of Medicine, Richmond, VA, USA


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BACKGROUND: Mesenchymal stem cells can be differentiated into muscle satellite cells. Testosterone replacement therapy (TRT) promotes the differentiation of satellite cells into muscle cells.
CASE REPORT: A 31 year old male with a T4 complete chronic spinal cord injury (SCI) had fixation for a mid-shaft fracture of the left femur. The participant received transdermal testosterone patches (4mg/day) daily for 16 weeks. Skeletal muscle and yellow bone marrow adiposity cross-sectional areas (CSAs) of both thighs were measured using magnetic resonance imaging.
CLINICAL REHABILITATION IMPACT: The yellow bone marrow CSA was 67-69% lower in the left femur compared to the right femur. Following intervention, a discrepancy was noted between the whole skeletal muscle CSAs of the right (+13%) and left (+6%) thighs. The right knee extensor CSA increased by 7% with no changes in the left CSA. Disruption in bone marrow fat may attenuate the systemic effects of TRT on muscle size.


KEY WORDS: Testosterone - Bone marrow - Mesenchymal stem cells - Spinal cord injuries

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ashraf.gorgey@va.gov