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EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
Rivista di Medicina Fisica e Riabilitativa dopo Eventi Patologici
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Indexed/Abstracted in: CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,063
European Journal of Physical and Rehabilitation Medicine 2016 April;52(2):223-32
Effects of home-based exercise training on VO2 in breast cancer patients under adjuvant or neoadjuvant chemotherapy (SAPA): a randomized controlled trial
Thibault CORNETTE 1, 2, François VINCENT 1, 2, Stephane MANDIGOUT 3, Marie T. ANTONINI 1, Sophie LEOBON 4, Anaïs LABRUNIE 5, Laurence VENAT 4, Sandrine LAVAU-DENES 4, Nicole TUBIANA-MATHIEU 2, 4 ✉
1 Department of Physiology, University Hospital, Limoges, France; 2 Faculty of Medicine, EA3842, University of Limoges, Limoges, France, 3 Faculty of Medicine, EA6310, University of Limoges, Limoges, France; 4 Department of Medical Oncology, University Hospital, Limoges, France; 5 Department of Biostatistics and Clinical Research, University Hospital, Limoges, France
BACKGROUND: Breast cancer chemotherapy is associated with a decline in measured cardiorespiratory fitness and increased fatigue. Physical activity has emerged as a feasible intervention to limit these side effects. Quantitative evaluation is necessary to propose a better-adapted physical activity and to evaluate efficacy.
AIM: We undertook a prospective study to assess the effects of a home-based adapted physical activity (APA) program on aerobic capacity, strength, and fatigue in women treated with adjuvant or neoadjuvant chemotherapy for breast cancer versus usual care.
DESIGN: This was an open two-arm, randomized controlled trial.
SETTING: Study included outpatient groups in the Department of Physiology and Medical Oncology of a hospital in France.
POPULATION: Forty-four patients treated with adjuvant or neoadjuvant chemotherapy for breast cancer.
METHODS: Patients were randomly assigned to a control group or an APA group. Intervention consisted of a 3-week, home-based, supervised, combined APA program (endurance and resistance training) during 27 weeks. The primary endpoint was cardiopulmonary function assessed by maximal peak oxygen consumption (VO2peak). Secondary endpoints included a 6-minute Walking Test (6MWT), and assessment of muscular strength, fatigue, quality of life, physical activity level, and anxiety/depression.
RESULTS: At 27 weeks, VO2peak increased by 1.83±0.68 ml.min-1.kg-1 in the APA group (P=0.009) and decreased by 1.31±0.65 mL.min-1.kg-1 in the control group (P=0.046). The difference between the two groups was not significant (2.26±1.53 mL.min-1.kg-1, P=0.140) in intention-to-treat analysis, but it was significant in per protocol analysis (3.49±1.64 mL.min-1.kg-1, P=0.049). At 27 and 54 weeks, no significant differences were observed between the two groups for the cardiopulmonary exercise test, 6MWT, quadriceps strength, or quality of life.
CONCLUSIONS: In breast cancer patients, a home-based supervised program during chemotherapy and radiotherapy treatment may be safe, feasible and increase VO2peak. In this study, heavy evaluation tests explain patient’s non-adherence and do not permit to obtain statistically significant results between APA and control groups.
CLINICAL REHABILITATION IMPACT: Aerobic home-based adapted physical activity is beneficial on aerobic capacity.