N. prodotti: 0
Totale ordine: € 0,00
Official Journal of the , , , ,
In association with
Indexed/Abstracted in: CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,063
Feltham M. G. 1, Collett J. 2, Izadi H. 3, Wade D. T. 4, Morris M. G. 2, Meaney A. J. 2, Howells K. 2, Sackley C. 5, Dawes H. 2, 6
1 Primary Care Clinical Sciences, School of Health and Population Sciences, University of Birmingham, Birmingham, UK;
2 Movement Science Group, School of Life Sciences, Oxford Brookes University, Oxford, UK;
3 Department of Mathematical Sciences, School of Technology, Oxford Brookes University, Oxford, UK;
4 Nuffield Orthopaedic Centre, Oxford Centre for Enablement, Oxford, UK;
5 School of Allied Health Professions, Faculty of Medicine and Health Sciences, Norwich Research Park Norwich, Norfolk, UK;
6 Department of Clinical Neurology, University of Oxford, Oxford, UK
Background: Guidelines for optimal exercise doses in people with multiple sclerosis (MS) have to be established. We need to ascertain the basic physiological and perceptual response and adaptation to different exercise doses in this clinical population.
Aim: The aim of this paper was to explore the response during maximal and sub-maximal exercise in people with MS prior to and following two different twelve week exercise programmes.
Design: Sub-analysis of per protocol exercise data of a two group, single blinded, randomised control trial.
Setting: Multicentre (community leisure and rehabilitation centres).
Population: Participants with MS assigned to a continuous (N.=12; mean±SE age=52.3±2.08; Barthel index median & range=19&13-20) or interval (N.=9; mean±SE age=49.3±3.5; Barthel index median & range=19&18-20) exercise programme.
Methods: Cardiovascular, respiratory and perceptual exercise response and adaption was measured at maximal and sub-maximal levels of physical exercise prior to and following a twelve week exercise programme, delivered at different intensities.
Results: Irrespective of the type of exercise programme followed, there was a significant increase in peak power (z=-1.98; P=0.05) and normalised oxygen uptake during unloaded cycling (z =-2.00; P=0.05). At discharge from the exercise programmes, the cardiovascular response to sub-maximal exercise had significantly changed (t(360) =-4.62; p<0.01).
Conclusion: The response in people with MS at maximal and sub-maximal levels of physical exercise following a twelve week programme is analogous to non-diseased adults.
Clinical Rehabilitation Impact: Cardiovascular adaptation in people with MS following a twelve week exercise programme suggests deconditioning rather than autonomic dysfunction caused by the disease.