Home > Riviste > European Journal of Physical and Rehabilitation Medicine > Fascicoli precedenti > European Journal of Physical and Rehabilitation Medicine 2013 Febbraio;49(1) > European Journal of Physical and Rehabilitation Medicine 2013 Febbraio;49(1):111-7

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE

Rivista di Medicina Fisica e Riabilitativa dopo Eventi Patologici


Official Journal of the Italian Society of Physical and Rehabilitation Medicine (SIMFER), European Society of Physical and Rehabilitation Medicine (ESPRM), European Union of Medical Specialists - Physical and Rehabilitation Medicine Section (UEMS-PRM), Mediterranean Forum of Physical and Rehabilitation Medicine (MFPRM), Hellenic Society of Physical and Rehabilitation Medicine (EEFIAP)
In association with International Society of Physical and Rehabilitation Medicine (ISPRM)
Indexed/Abstracted in: CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,063


eTOC

 

REVIEWS  


European Journal of Physical and Rehabilitation Medicine 2013 Febbraio;49(1):111-7

lingua: Inglese

Sarcopenia and fragility fractures

Cederholm T. 1, Cruz-Jentoft A. J. 1, Maggi S. 3

1 Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, and Department of Geriatric Medicine, Uppsala University Hospital, Uppsala, Sweden;
2 Geriatric Department, Hospital Universitario Ramón y Cajal, Madrid, Spain;
3 CNR Aging Branch, Institute of Neuroscience, Padua, Italy


FULL TEXT  


Sarcopenia, a reduction in muscle mass and muscle function, is considered one of the hallmarks of the aging process. Current views consider sarcopenia as the consequence of multiple medical, behavioural and environmental factors that characterize aged individuals. Likewise bone fragility is known to depend on several pathogenetic mechanisms leading to bone mass loss and reduction of bone strength. Muscle weakness, fear of falls, falls and subsequent fractures are associated to concurrent sarcopenia and osteoporosis and lead to restricted mobility, loss of autonomy and reduced life expectancy. The skeletal and the muscular organ systems are tightly intertwined: the strongest mechanical forces applied to bones are, indeed, those created by muscle contractions that condition bone density, strength, and microarchitecture. Not surprising, therefore, the decrease in muscle strength leads to lower bone strength. The degenerative processes leading to osteoporosis and sarcopenia show many common pathogenic pathways, like the sensitivity to reduced anabolic hormone secretion, increased inflammatory cytokine activity and reduced physical activity. Thus they may also respond to the same kind of treatments. Basic is life-style interventions related to exercise and nutrition. Sufficient vitamin D levels are of importance for both bone and muscle, primarily provided by sun exposure at younger age, and by supplementation at older age. Resistance training several times per week is crucial, and to be effective adequate access to energy and proteins is necessary.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

stefania.maggi@in.cnr.it