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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Jul 13

DOI: 10.23736/S0392-0488.17.05592-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

The anti-inflammatory and antioxidant properties of 1,2-decanediol and willow bark extract in lipopolysaccharide-stimulated keratinocytes

Roberta DI CAPRIO 1 , Giuseppe MONFRECOLA 1, Anna BALATO 2, Nicola BALATO 1, Franco GASPARRI 3, Raffaella MICILLO 1, Serena LEMBO 4

1 Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 2 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; 3 Department of Pharmacy (DIFARMA), University of Salerno, Salerno, Italy; 4 Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy


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BACKGROUND: The 1,2-decanediol (S-Mal) is an organic compound belonging to the 1,2- alkanediol family, with two hydroxyl groups located on the first and second carbon of the alkane chain, probably responsible for the enhanced anti-bacterial efficacy. The willow bark total extract (W-Mal) has been used since thousands of years as an herbal remedy for its antipyretic, analgesic, anti-inflammatory and anti-microbial activities. S-Mal is used in cosmetic preparations, whether W- Mal can be topically or systemically administered. Aim of our study was to evaluate in vitro the anti-inflammatory and antioxidant properties of S-Mal and W-Mal, singularly or in combination, in LPS-stimulated keratinocytes.
METHODS: The possible toxic effect of S-Mal and W-Mal was assessed through analysis of cell viability 24h after treatment. The anti-inflammatory and antioxidant activities were evaluated by measuring IL-8, TNF-α and IL-1β production as well as cellular antioxidants (GSH and NADPH) consumption, respectively, 24 and 48h after LPS stimulation.
RESULTS: Both substances resulted able to: i) increase cell viability (P < 0.05), ii) decrease the release of inflammatory mediators (IL-8, TNF-α and IL-1β) (P < 0.05- P < 0.001), and iii) limit the depletion of cellular antioxidants (GSH and NADPH) (P < 0.001).
CONCLUSIONS: S-Mal and W-Mal have shown a potential cytoprotective activity when used together, and good anti-inflammatory and antioxidant effects when used either singularly or in combination. In light of our results, S-Mal and W-Mal could represent effective and safe options in the management of bacterial-induced or aggravated skin conditions.


KEY WORDS: 1,2-decanediol - Anti-inflammatory properties - Antioxidant effects - Willow bark extract

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Publication History

Article first published online: July 13, 2017
Manuscript accepted: July 13, 2017
Manuscript revised: July 5, 2017
Manuscript received: January 25, 2017

Per citare questo articolo

Di Caprio R, Monfrecola G, Balato A, Balato N, Gasparri F, Micillo R, et al. The anti-inflammatory and antioxidant properties of 1,2-decanediol and willow bark extract in lipopolysaccharide-stimulated keratinocytes. G Ital Dermatol Venereol 2017 Jul 13. DOI: 10.23736/S0392-0488.17.05592-4

Corresponding author e-mail

rob.dicaprio@libero.it