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Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Oct 05
Antibodies against antigens related to Scleroderma in a cohort of patients with Morphea
Mariachiara ARISI 1, Ilaria CAVAZZANA 2, Maria E. CERUTTI 2, Fabio FERRARI 2, Nice CARABELLESE 2, Maria T. ROSSI 1, Angela TINCANI 2, Pier G. CALZAVARA-PINTON 1, Franco FRANCESCHINI 2
1 Department of Dermatology, Spedali Civili and University of Brescia, Brescia, Italy; 2 Rheumatology and Clinical Immunology, Department of Medicine, ASST Spedali Civili and University of Brescia, Brescia, Italy
BACKGROUND: Morphea is a rare fibrosing skin disorder. Antinuclear antibodies (ANA), antihistone and rheumatoid factor are detected in high rate of morphea cases. Scleroderma-related antibodies are usually absent.
METHODS: 21 adult patients affected by morphea were examined at the time of enrollment and after 6 months with the assessment of clinical outcome measures of disease severity and damage. Healthy subjects were considered as normal controls while patients affected by systemic sclerosis and other connective tissue diseases (CTD) were considered as pathological controls. Serum samples from all the patients and controls were analysed for the detection of ANA, anti-nucleosome antibodies, anti-dsDNA and anti-ENA. Scleroderma-related autoantibodies were searched using a line-blot test.
RESULTS: We enrolled 21 patients affected by morphea. ANA were found in 12 patients (57%). Anti-DNA and anti-nucleosome antibodies were negative in all cases. SSc-specific antibodies were found in 11 morphea patients (52.4%) and 1 healthy controls (6.25%). In patients affected by Systemic Sclerosis (100%) and different CTD (%), scleroderma-related autoantibodies were more frequently detected than in morphea (52.4%). In morphea, anti-TRIM21/Ro52 antibodies were found in 4 patients (36.4%) and resulted to be the most frequently detected antibodies also in two groups of SSC and CTD.
CONCLUSIONS: The high prevalence of ANA and the identification of some anti Ssc-related autoantibodies, confirm the idea of a significant activation of autoimmune system in morphea.