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Rivista di Dermatologia e Malattie Sessualmente Trasmesse

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2016 Apr 20

lingua: Inglese

Intralesional (incision) biopsy for melanoma diagnosis: the rules and the exception to the rules

Elvira MOSCARELLA 1, Giuseppe ARGENZIANO 2, Claudia MORENO 3, Simonetta PIANA 4, Aimilios LALLAS 1, Mara LOMBARDI 1, Caterina LONGO 1, Gerardo FERRARA 5

1 Dermatology and Skin Cancer Unit, 1st Medical Department, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy; 2 Dermatology Department, Second University of Dermatology, Naples, Italy; 3 Dermatology Department, Clinical Hospital University of Chile, Santiago, Chile; 4 Department of Dermatopathology, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy; 5 Anatomic Pathology Unit, Gaetano Rummo General Hospital, Benevento, Italy


Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for lesions whose in toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, or traumatic skin changes, rather then nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.

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