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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Mar 18
Predictive factors in non-melanoma skin cancers treated with electrochemotherapy
Roberta ROTUNNO, Giovanni PAOLINO, Carmen CANTISANI, Carmen SOLITO, Stefano CALVIERI, Pietro CURATOLO ✉
Dermatologic Clinic of University of Rome "La Sapienza", Rome, Italy
BACKGROUND: The management of non-melanoma skin cancers may benefit from alternative treatments and in this spectrum electrochemotherapy plays a pivotal role. The aim was to describe the predictive features of patients with cutaneous carcinomas treated with electrochemotherapy, with regard to clinical, pathological and instrumental predictors.
METHODS: We analysed disease free survival (DFS), and overall survival (OS) for each patient. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Cox-proportional hazards regression in both univariate and multivariate analyses.
RESULTS: We can assess that in the brief-term (DFS), the patients’ age, tumour-site, tumour size, photo-type and the dose of the cytotoxic drug showed a statistical significant better behaviour. However, in the multivariate, only the variables tumour’s site (p = 0.01) and tumour appearance (p= 0.03) reached the statistical significance. In the long-term, female patients, patients with a median age ≤ 70 years, with III-IV photo types and patients, which received a dosage of bleomycin, ≤ 14 mg/m2 presented a significant better behaviour. However in the multivariate analysis a significance was maintained for the variables tumour’s appearance (HR: 11.6; 95%IC: 11.56 to 27.5; p =0.01;), infiltration (HR:0.11; 95%IC: 0.012 to 0.9; p=0.04), electrode type (HR:0.19; 95%IC:0.04 to 0.8; p=0.03;) and photo type (HR:5.7; 95%IC:1.3 to 24.3; p=0.01).
CONCLUSIONS: According to our results, in electrochemotherapy different individual variables can have an important influence, which shows how this treatment could improve. The refinement of the technique and the optimization of patients’ selection has the aim to improve the therapeutic response.