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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2015 Oct 20
Preliminary results of the application of a disease activity score in a patient with relapsing polychondritis
Pinto A. C. 1, Wachholz P. A. 2, Masuda P. Y. 1, Freitas F. B. 1, Cavalcante M. L. 1, Soares C. T. 1 ✉
1 Dermatology Department, Instituto Lauro de Souza Lima, Bauru, São Paulo, Brazil;
2 Public Health Department, Faculdade de Medicina de Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo, Brazil
AIMS: The present study aims to report a case of Relapsing Polychondritis, using established diagnostic criteria, and evaluate preliminary results of the Relapsing Polychondritis Disease Activity Index (RPDAI), before and after treatment with a combination of corticosteroids and colchicine.
CASE REPORT: Twenty one years old female with ocular photosensitivity, tearing and bilateral erythema since last pregnancy. Symptoms remitted spontaneously after pregnancy. Three months later symptoms relapsed, added to bilateral auricular chondritis (sparing ear lobe), frequent episodes of hoarseness and aphonia, and pain during esternal and chostocondral palpation. Histopathological examination exhibited skin with inflammatory infiltrate, increased fibroblasts and loss of basophilic staining of the cartilage matrix. This patient fulfilled requirements to diagnosis of RP in the three different criteria. At admission, RPDAI score was 35 points; 12 months after treatment with prednisone and colchicines, score decreased to nine points.
CONCLUSION: Preliminary results of RPDAI application helped to measure the progress in RP in this case report. Its potential to early detection of recurrences may help clinicians on therapeutic approach, and reinforces the premise that early institution of treatment has a positive impact on the prognosis of these patients.