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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Casari A. 1, Argenziano G. 2, Piana S. 3, Lallas A. E. 2, Moscarella E. 2, Lombardi M. 2, Raucci M. 2, Pellacani G. 1, Longo C. 2
1 Department of Dermatology, University of Modena and Reggio Emilia, Italy;
2 Skin Cancer Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy;
3 Pathology Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
BACKGROUND: Merkel cell carcinoma (MCC) is a cutaneous carcinoma with neuroendocrine differentiation. It arises typically on sunexposed areas of elderly men as an asymptomatic, rapidly growing, red nodule. Although it is usually found as a solitary nodule, in almost one third of cases MCC may be associated with other malignancies such as basal cell or squamous cell carcinomas.
OBJECTIVE: Merkel cell carcinoma should be considered as differential diagnosis everytime we have a rapidly growing, red nodule, arising in an elderly patient with signs of sun-damage.
METHODS:We report a case of MCC developing in association with a pre-existing Bowen's disease.
RESULTS: The association between MCC and Bowen's disease is quite common and their area of occurence is usually a sun-exposed area.
CONCLUSIONS: Ultraviolet radiation contributes to the etiology of both the malignancies.