Home > Riviste > Giornale Italiano di Dermatologia e Venereologia > Fascicoli precedenti > Giornale Italiano di Dermatologia e Venereologia 2017 June;152(3) > Giornale Italiano di Dermatologia e Venereologia 2017 June;152(3):302-7

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014


eTOC

 

REVIEW  


Giornale Italiano di Dermatologia e Venereologia 2017 June;152(3):302-7

DOI: 10.23736/S0392-0488.17.05567-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

“Active” photoprotection: sunscreens with DNA repair enzymes

Matteo MEGNA , Serena LEMBO, Nicola BALATO, Giuseppe MONFRECOLA

Department of Dermatology, Federico II University, Naples, Italy


PDF  


Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a “passive photoprotection” and are not effective once damage to skin cells has been generated after sun exposure. Conversely, “active” photoprotection is represented by topical sunscreens including also antioxidants and liposome-containing DNA repair enzymes, which may constitute a photostrategy filling the current gap in sun protection. In the current review, we focused on “active” photoprotection at a topical level, reporting present knowledge and future prospective regarding DNA repair enzymes such as photolyase, endonuclease and 8-oxoguanine glycosylase which are able to enhance the protective power of traditional sunscreens.


KEY WORDS: Sun protection factor - Skin care - Endonucleases - Deoxyribodipyrimidine photo-lyase - Human oxoguanine glycosylase 1 - DNA damage - DNA repair

inizio pagina

Publication History

Issue published online: April 13, 2017
Article first published online: February 16, 2017
Manuscript accepted: January 30, 2017
Manuscript received: January 7, 2017

Per citare questo articolo

Megna M, Lembo S, Balato N, Monfrecola G. “Active” photoprotection: sunscreens with DNA repair enzymes. G Ital Dermatol Venereol 2017;152:302-7. DOI: 10.23736/S0392-0488.17.05567-5

Corresponding author e-mail

mat24@libero.it