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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Ottobre;151(5):473-9
Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo
Lamia H. ELGARHY 1, Amani ABDULLATIF 1, Rehab ABDELAZIM 2, Karima I. EL-DESOUKY 3 ✉
1 Department of Dermatology and Venereology, Tanta University, Tanta, Egypt; 2 Mehalla Hospital, Tanta, Egypt; 3 Department of Pathology, Tanta University, Tanta, Egypt
BACKGROUND: The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis.
METHODS: Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression.
RESULTS: Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found.
CONCLUSIONS: Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.