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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 June;151(3):230-8
Efficacy, tolerability, impact on quality of life and sebostatic activity of three topical preparations for the treatment of mild to moderate facial acne vulgaris
Giuseppe STINCO 1, Fabio PICCIRILLO 1, Francesca VALENT 2, Enzo ERRICHETTI 1, Nicola DI MEO 3, Giusto TREVISAN 3, Pasquale PATRONE 1 ✉
1 Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, Udine, Italy; 2 Institute of Hygiene and Epidemiology, University of Udine, Udine, Italy; 3 Institute of Dermatology and Venereology, University of Trieste, Trieste, Italy
BACKGROUND: Acne is treated according to the clinical observations and pathophysiologically relevant mechanisms, such as hyper-keratinization, seborrhea and bacterial proliferation. In mild and moderate forms of inflammatory acne, topical antimicrobials are recommended as a monotherapy or in combination with topical retinoids. The aim of this study was to compare the clinical effectiveness, tolerability, impact on quality of life and effect on sebum excretion of three antimicrobial preparations: clindamycin phosphate, benzoyl peroxide and a combination of clindamycin phosphate plus benzoyl peroxide.
METHODS: In total, 240 patients were randomized into treatment groups for an 8-week study. Every two weeks the patients were evaluated using the following methods: photography, the Global Acne Grading System, sebumetric evaluation, and the Acne-Specific Quality of Life questionnaire. In addition, 80 healthy controls were enrolled for the sebumetric evaluation.
RESULTS: A significant improvement in acne and the quality of life was observed for all three therapies at the end of the study. The sebum excretion results for the three treatment groups displayed significant and unpredictable variation, whereas the controls groups exhibited no significant variation. The three treatments were well tolerated.
CONCLUSIONS: The efficacy of the three antimicrobial preparations likely results from their anti-inflammatory and bacteriostatic activities. In contrast, seborrhoea seems to be minimally impacted.