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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
Rivista di Dermatologia e Malattie Sessualmente Trasmesse
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2015 Agosto;150(4):351-5
Comparison of the efficacy and safety of zinc sulfate vs. placebo in the treatment of pruritus of hemodialytic patients: a pilot randomized, triple-blind study
Mapar M. A. 1, Pazyar N. 1, Siahpoosh A. 2, Latifi S. M. 3, Beladi Mousavi S. S. 4, Khazanee A. 5 ✉
1 Dermatology, Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;
2 Pharmacognesy, Faculty of Pharmacology, Medical Plants and Natural Products Research, Ahvaz, Iran;
3 Department of Biostatics, Faculty of Health, Member of Ahvaz Diabetics Research Center, Ahvaz, Iran;
4 Internal Medicine, Department of Internal Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;
5 Dermatologist, Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AIM: Improvement of uremic pruritus has been reported under short-term administration of oral zinc sulfate. Objective of the study was to confirm efficacy and safety of oral zinc sulfate in pruritus of hemodialytic patients
METHODS: A pilot randomized, triple-blind study was conducted to evaluate the pruritus of hemodialytic patients. Forty eligible patients were screened and assigned to receive either zinc sulfate (220 mg/d) or matched placebo for a 4-week trial. Pruritus scale was evaluated at the initiation of the study and 1, 2, 3, and 4 weeks after the treatment. We used a modified score proposed by Duo assessing pruritus severity, distribution of pruritus, and frequency of pruritus-related sleep disturbance.
RESULTS: Thirty-six patients completed the study. The mean pruritus score decreased in both groups during the first and the second weeks of trial; however, it was more prominent in zinc group than placebo one. In the zinc group, 4 (20%) patients showed pruritus discontinuation during treatment period whereas, in the placebo group, the number was only 1 (5%) patient. Nonetheless, T-test revealed no statistically significant difference between the zinc and placebo groups (P=0.88 and P=0.56, respectively).
CONCLUSION: Our findings demonstrated that oral zinc sulfate (220 mg/d) during four weeks treatment might be safe and effective in discontinuation of uremic pruritus, but it was not significant. This could be because of the small number of patients; therefore, we suggest conducting more studies with larger sample size.