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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2015 Giugno;150(3):331-5

lingua: Inglese

Photodynamic therapy for the treatment of microinvasive squamous cell carcinoma of the lower lip: a case report

Fargnoli M. C. 1, Kostaki D. 1, Piccioni A. 1, Di Stefani A. 2, Peris K. 1

1 Department of Dermatology, University of L’Aquila, L’Aquila, Italy;
2 Departments of Dermatology and Pathology, University of Rome “Tor Vergata”, Rome, Italy


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Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is approved in Europe for the treatment of actinic keratosis and Bowen’s disease, both intraepithelial forms of squamous cell carcinoma (SCC). A therapeutic effect of MAL-PDT has been recently suggested for superficial, microinvasive and well-differentiated cutaneous SCC. We describe the successful use of MAL-PDT in a recently observed patient with microinvasive SCC of the lower lip and review published data on the use of PDT with MAL or d-aminolevulinic acid (ALA) in cutaneous microinvasive SCC. A patient with a biopsy-proven recurrent microinvasive SCC of the lower lip was treated with 2 cycles of MAL-PDT. Complete clinical, dermoscopic and histopathological clearance was obtained after 2 cycles of MAL-PDT with an excellent cosmetic result and a sustained remission after 24-month follow-up. A review of the few studies reporting on the use of MAL-PDT or ALA-PDT for cutaneous microinvasive SCCs was carried out. MAL-PDT might represent a non-invasive treatment option for microinvasive SCC of the lower lip if patients are not eligible for surgery. Post-treatment histopathological confirmation and a long-term follow-up are strictly recommended.

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ketty.peris@univaq.it