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Rivista di Chirurgia
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Chirurgia 2017 June;30(3):79-83
Copyright © 2016 EDIZIONI MINERVA MEDICA
A comparative study of homocysteine levels in patients undergoing coronary bypass
Kambiz ALIZADEH 1, Masoomeh TABARI 2 ✉, Farahnaz Z. AVAL 3, Leila MASHHADI 4, Azra IZANLOO 2
1 Department of Cardiac Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2 Cardiac Anesthesia Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 3 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 4 Department of Anesthesiology, Mashhad University of Medicine, Mashhad, Iran
BACKGROUND: Cardiac biomarkers have been integral to the primary and secondary diagnosis and management of acute myocardial infarction and heart failure in cardiology over the past 50 years. However, the importance of homocysteine as a biomarker of coronary heart disease still remains unclear. Accordingly, this study was designed to measure homocysteine levels in patients with advanced coronary artery atherosclerosis scheduled for coronary bypass surgery and to examine the relationship between homocysteine levels and the severity of disease and variables under study.
METHODS: The study population consisted of 80 subjects with coronary atherosclerosis referred to the Department of Heart Surgery at General Hospital of Mashhad, Iran. Homocysteine serum levels were measured via enzyme immunoassay (Axis-Shield). The relationship between results and severity of clogged vessels (one, two, three and four or more clogged vessels) as well as the results of lipid profile were investigated.
RESULTS: There was a significant relationship between serum levels of homocysteine and the number of vessels (P=0.01). Patients with four or more clogged vessels had higher levels of homocysteine (22 µmol/L) than patients with three (16 µmol/L) and two (13.75 µmol/L) clogged vessels.
CONCLUSIONS: The level of homocysteine in CAD patients was investigated and explored the possibility of its application as a biomarker for the severity of coronary artery blockage. There was a significant difference between homocysteine levels and the number of clogged vessels in patients. Further studies with larger sample sizes are recommended to assess the clinical utility of this test as a prognostic biomarker.
KEY WORDS: Homocysteine - Coronary artery disease - Atherosclerosis