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Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1782
Ge Y. 1, Wang P. 2, Xu Y. 2, Miao Q. 3, Yu H. 4, Liu Z. 1, Li T. 1
1 Department of Infectious Disease, Peking Union Medical College Hospital,, Chinese Academy of Medical Sciences, Beijing, China;
2 Department of Clinical Laboratory, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Beijing, China;
3 Department of Cardiac Surgery, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Beijing, China;
4 Peking Union Medical College and Tsinghua University, Beijing, China
AIM: Endocarditis caused by Microascus trigonosporus is rarely reported. Here we report a case of a 46-year-old man with endocarditis caused by M. trigonosporus after cardiac pacemaker implantation.
METHODS: This strain of Microascus trigonosporus was isolated from the pacemaker surface. Histopathology sections from the biopsied vegetations lesion demonstrated abundant septate hyphae and intercalary swollen chlamydospores was consistent with a fungal etiology. This paper studied the Microascus trigonosporus characteristic and ITS region was amplified and sequenced. Antifungal drugs susceptibility test was also performed in vitro.
RESULTS: The Etest result showed that MIC of itraconazole is ≥32 µg/mL, amphotericin B is ≥32 µg/mL, however voriconazole is 4 µg/mL. Vegetations were removed by surgical debridement and voriconazole was used. After that, the patient recovered with the normal temperature in a short time and resulted in a favorable outcome.
CONCLUSION: With the rising incidence of fungi infections, clinicians should be aware of the opportunistic infections caused by Microascus and remain alert.