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Rivista di Chirurgia

Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index

Periodicità: Bimestrale

ISSN 0394-9508

Online ISSN 1827-1782


Chirurgia 2014 Ottobre;27(5):289-91


Report of a rare case of myofibroblastoma of the breast in a woman

Accurso A. 1, Cozzolino I. 2, Varone V. 3, Della Corte G. A. 1, Pettinato G. 3, Ciancia G. 3, Rocco N. 1

1 Department of General, Geriatric, Oncologic Surgery and Advanced Technologies, University Federico II of Naples, Naples, Italy;
2 Department of Public Health, University Federico II of Naples, Naples, Italy;
3 Department of Advanced Biomedical Sciences, University Federico II of Naples, Naples, Italy

Myofibroblastoma is a rare, benign mesenchymal tumour of the breast. Since its first description by Wargotz in 1987, less than 70 cases have been reported in literature, mostly in males. We report a case of a 64-year-old woman with a 2,5 cm lump in the upper-outer quadrant of her left breast. She underwent Ultrasound-guided Fine Needle Aspiration Citology (US-FNAC) of the lesion that showed a mesenchimal proliferation without atypia. Excisional biopsy was performed and histological examination showed a spindle cell proliferation without cellular atypia and aboundant dense fibrous collagen, in absence of mammary ducts and lobules. Spindle cells resulted positive for vimentin, CD34, desmin, H-caldesmon, CD99, bcl2 and actin and were negative for cytokeratins and S-100. The morphologic features, in conjunction with the immunophenotype, were consistent with a myofibroblastoma of the breast (classic type). The patient did not perform any other medical adjuvant treatment in relation to the benign behaviour of these kind of lesions reported in literature.

lingua: Inglese


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