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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Lukla BIASI 1, Sanjay D. PATEL 1, Talia LEA 1, Tommaso DONATI 1, Konstantinos KATSANOS 2, Judith S. PARTRIDGE 3, Jugdeep K. DHESI 3, Hany ZAYED 1
1 Guy’s St.Thomas’ NHS Foundation Trust, Department of Vascular and Endovascular Surgery, London, England; 2 Guy’s St.Thomas’ NHS Foundation Trust, Department of Radiology, London, England; 3 Guy’s St.Thomas’ NHS Foundation Trust, Department of Ageing and Health, London, England
BACKGROUND: The incidence of Critical Limb Ischaemia (CLI) is exponentially rising among our aging population. There is a paucity of scientific evidence on best management and clinical outcome of infra-popliteal (IP) revascularisation in elderly CLI patients.
METHODS: A prospectively collected database was analysed to identify consecutive octogenarian and nonagenarian patients who underwent IP revascularisation (bypass or angioplasty) for CLI (Rutherford 4-6) in a single centre between 2010-2014. The primary end points were overall Amputation-Free-Survival (AFS) and Overall Survival (OS) at 1 and 2 years. Secondary endpoints were primary, assisted-primary, secondary patency and Limb-Salvage (LS) rates by Kaplan-Meier analysis. Univariate and multivariate analysis was performed to find factors predicting outcome.
RESULTS: A total of 129 limbs in 120 patients were treated with IP bypass (n=42) and endovascular (n=87) revascularisation with a mean age of 85(±5) years. The overall primary patency, assisted-primary patency and secondary patency were 58%, 65% and 70%, respectively at 12 months and 34%, 48% and 59% at 24 months. Primary, assisted-primary and secondary patency analysed by treatment method (endovascular vs. bypass) was 54% vs. 52%, 61% vs. 70%, 69% vs. 75% at 1 year and 21% vs. 36%, 24% vs. 62%, 31% vs. 72% at 2 years. The overall AFS at 12 and 24 months was 62% and 46% respectively; AFS was 71%-68% in the bypass group and 53%-21% in the Endovascular group (P<0.001). LS was 89% at 12 months and 84% at 24 months, with no significant difference between the bypass and endovascular groups (P=0.24). The overall perioperative mortality rate was 2%. OS by Kaplan-Meier was 68% and 54% at 1 and 2 years respectively. Diabetes (P=.046) and low eGFR (P=.041) were predictors of worse AFS and OS, respectively.
CONCLUSIONS: IP revascularisation (either endovascular or surgical) is feasible and effective in octogenarians and nonagenarians with CLI. By adopting a patient-tailored approach, both revascularisation strategies have satisfactory technical and clinical outcomes in this high-risk group. Subgroup analysis suggests that bypass surgery may have better mid-term secondary patency and AFS rates.