Home > Riviste > The Journal of Cardiovascular Surgery > Fascicoli precedenti > The Journal of Cardiovascular Surgery 2017 August;58(4) > The Journal of Cardiovascular Surgery 2017 August;58(4):624-32

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,179


eTOC

 

REVIEW  CARDIAC SECTION


The Journal of Cardiovascular Surgery 2017 August;58(4):624-32

DOI: 10.23736/S0021-9509.16.09382-4

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Better midterm survival in women after transcatheter aortic valve implantation

Hisato TAKAGI , Takuya UMEMOTO, on behalf of All-Literature Investigation of Cardiovascular Evidence (ALICE) group 

Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan


PDF  


INTRODUCTION: In previous meta-analyses demonstrating better midterm overall survival in women undergoing transcatheter aortic valve implantation (TAVI), unadjusted risk and odds ratios were combined. To determine whether female gender is independently associated with better survival after TAVI, we performed a meta-analysis pooling adjusted hazard ratios (HRs) based on multivariate Cox proportional hazard regression.
EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched through September 2015 using PubMed and OVID. Studies considered for inclusion met the following criteria: the study population was patients undergoing TAVI; and main outcomes included midterm (mean or median ≥6 months) overall survival or all-cause mortality in women and men. An unadjusted and/or adjusted HR of all-cause mortality for women versus men was abstracted from each individual study.
EVIDENCE SYNTHESIS: Of 1347 potentially relevant articles screened initially, 16 reports of eligible studies were identified and included. A primary meta-analysis of the 9 adjusted HRs demonstrated a significantly better midterm overall survival in women than men (N.=6891; HR=0.80; 95% confidence interval [CI]: 0.65 to 0.97; P=0.03). A secondary meta-analysis adding 5 statistically non-significant unadjusted HR also indicated better survival in women (N.=8645; HR=0.83; 95% CI: 0.72 to 0.96; P=0.01). Although statistical tests for the primary meta-analysis revealed funnel plot asymmetry in favor of women, the secondary meta-analysis produced a symmetrical funnel plot.
CONCLUSIONS: Female gender may be independently associated with better midterm overall survival after TAVI.


KEY WORDS: Transcatheter aortic valve replacement - Survival - Women - Meta-analysis

inizio pagina

Publication History

Issue published online: June 5, 2017
Article first published online: April 8, 2016
Manuscript accepted: April 6, 2016
Manuscript revised: March 21, 2016
Manuscript received: February 7, 2016

Per citare questo articolo

Takagi H, Umemoto T; All-Literature Investigation of Cardiovascular Evidence (ALICE) group. Better midterm survival in women after transcatheter aortic valve implantation. J Cardiovasc Surg 2017;58:624-32. DOI: 10.23736/S0021-9509.16.09382-4

All-Literature Investigation of Cardiovascular Evidence (ALICE) group

Corresponding author e-mail

kfgth973@ybb.ne.jp