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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Jan A. TEN BOSCH 1, Sam W. KONING 1, Edith M. WILLIGENDAEL 2, Marc R. VAN SAMBEEK 3, Rutger A. STOKMANS 3, 4, Martin H. PRINS 4, Joep A. TEIJINK 3, 4
1 Department of Surgery, Atrium Medical Centre Parkstad, Heerlen, The Netherlands; 2 Department of Surgery, Alkmaar Medical Centre Alkmaar, The Netherlands; 3 Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands; 4 Department of Epidemiology, Caphri Research School Maastricht University, Maastricht, The Netherlands
BACKGROUND: In patients with a symptomatic abdominal aortic aneurysm (sAAA), acute intervention theoretically reduces rupture risk prior to surgery whereas delayed intervention provides surgery under optimised conditions. In the present study we evaluated differences in 30-day mortality in patients with a sAAA operated within 12 hours compared to patients who received treatment after 12 hours and who were optimized for surgery.
METHODS: All patients with a sAAA who were treated within one week after presentation were included in the analyses. The 30-day mortality rates of patients operated within 12 hours were compared to those operated after 12 hours, adjusted for type of operation and for all potential confounders.
RESULTS: Of the 89 included patients, 37 patients received surgery within 12 hours. In patients treated within 12 hours, 30-day mortality rate was 6 (16.2%) compared to 3 (5.8%) in patients treated after 12 hours (odds ratio 0.316; CI 0.074-1.358). When adjusted for type of operation and other confounders, odds ratios were 0.305 (CI 0.066-1.405) and 0.270 (CI 0.015-4.836), respectively.
CONCLUSIONS: In a substantial amount of patients with an alleged symptomatic AAA, delayed surgery with patient optimisation might be justified. However, specific criteria in order to select patients that might benefit from delayed surgery need further investigation.