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THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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The Journal of Cardiovascular Surgery 2015 Agosto;56(4):671-80

lingua: Inglese

Role of biomarkers in management of complications after cardiac surgery

Zhang B. 1, 2, Liang J. 1, Zhang Z. 2

1 Department of Cardiovascular Surgery, The General Hospital of Jinan Military District, Jinan, PR China;
2 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, USA


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The use of cardiopulmonary bypass distinguishes cardiac surgery from other types of surgery. It introduces some serious postoperative complications, such as acute organ dysfunction of the brain, heart, kidney, lungs and infection, which cause significant morbidity and mortality. Prevention and control of these complications are critical in the evolution of cardiac surgery and in the successful outcomes of most operations. Early detection of these complications are clinically important, because many therapeutic interventions are available to prevent these deadly effects today. Many biomarkers have emerged over the past years, which provided superior diagnostic and prognostic information. Some specific biomarkers that can reflect organ dysfunction, may be useful for early detection, diagnostic assessment, risk stratification of these complications, even monitoring the patient’s response to therapy. Our expectation is that a cardiac surgery-associated monitoring system should be constructed with multiple biomarkers, which are specific for different postoperative complications. Such system may help physicians and anesthetist to tailor perioperative management, considering individual pathogenesis and prognosis. In this review, we will summarize the newly identified cardiac surgery-associated biomarkers, and discuss their values in diagnosis and prognosis of some serious complications.

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zhangj@unmc.edu