Ricerca avanzata

Home > Riviste > The Journal of Cardiovascular Surgery > Fascicoli precedenti > The Journal of Cardiovascular Surgery 2012 Dicembre;53(6) > The Journal of Cardiovascular Surgery 2012 Dicembre;53(6):805-8

FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOTHE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Periodicità: Bimestrale

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2012 Dicembre;53(6):805-8

 CASE REPORTS

Neutrophil gelatinase-associated lipocalin as emerging biomarker of acute renal failure in renal transplant patient after coronary artery bypass surgery

Ampatzidou F. 1, Koutsogiannidis C.-P. 2, Ananiadou O. 2, Liosi M. 3, Asteri T. 4, Drossos G. 2

1 Intensive Care Unit, G. Papanikolaou General Hospital, Thessaloniki, Greece;
2 Department of Cardiac Surgery, G. Papanikolaou General Hospital, Thessaloniki, Greece;
3 Department of Clinical Biochemistry, G. Papanikolaou General Hospital, Thessaloniki, Greece;
4 Department of Cardiothoracic Anesthesia, G. Papanikolaou General Hospital, Thessaloniki, Greece

Acute renal injury (AKI) is a serious complication, which increases the risk of death after cardiac surgery. Although serum Cre is typically used for diagnosis of AKI, there are disadvantages in its use as renal marker. Neutrophil gelatinase-associated lipocalin (NGAL) is a protein of the lipocalin family and is expressed by neutrophils and other epithelial cells including segments of proximal collecting tubule (PCT). It is introduced as an excellent renal biomarker, for the early diagnosis of AKI in children and adults undergoing renal transplantation and cardiac surgery. According to literature data NGAL is detected in the very first urine sample within two hours following ischemia. It is one of the earliest and most robustly induced proteins in kidneys following ischemic and nephrotoxic insults. We present an interesting case of renal transplant patient under long-term immunosuppressive therapy. He had already renal impairment of the transplant kidney (GFR 29.3 mL/min/1.73 m2). He suffered from coronary artery disease without history of myocardial infraction and underwent elective coronary artery bypass grafting (CABG). Renal function was monitored also with NAGL, in order to avoid potential renal graft failure postoperatively.

lingua: Inglese


FULL TEXT  ESTRATTI

inizio pagina