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Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632
Online ISSN 1827-191X
Gurbanov E. 1, Meng X. 1, Cui Y. Q. 1, Jia Y. X. 1, Zeng W. 1, Han J. 1, Shi J. H. 2
1 Ninth Cardiac Surgery Ward, Anzhen Hospital of the Capital Medical University, Beijing, Republic of China;
2 Cardiothoracic Department, Hospital of Nantong University, Nantong, Republic of China
AIM: This study documents our experience with the use of ECMO in adult cardiac transplantation. Furthermore, in an attempt to improve outcomes of donor hearts with long ischemic times (LITs) we evaluated the efficacy of a strategy based on intraoperative ECMO (i-ECMO) circuit extended into postoperative cardiopulmonary support.
METHODS:From February 2005 to September 2009, 11 patients (i-ECMO group) receiving allografts with LITs >7 hours underwent intraoperative ECMO circuit strategy with routine extension of ECMO into postoperative period. Eleven contemporary patients (s-CPB group) received ECMO support after standard CPB at the various intervals after the transplantation as a salvage therapy.
RESULTS: Overall weaning rate was 86.4%; overall 30-day and 1-year survival rates were 81.8% and 72.7%, respectively. There was no difference in mortality between the two groups. Length of stay in the intensive care unit, the requirement for packed red blood cells administration and the total in-hospital cost were significantly reduced in i-ECMO group patients (P<0.05).
CONCLUSION: The salvage of failing cardiac allograft with ECMO allows effective stabilization of the hemodynamic and leads toward myocardial recovery. Extending ECMO into postoperative period provides early, continues and effective support for donor hearts with LITs and maximizes the use of such marginal organs.