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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES CARDIAC SECTION
The Journal of Cardiovascular Surgery 2004 February;45(1):27-30
Platelet activity of residual blood remained in the cardiopulmonary bypass circuit after cardiac surgery
Tanemoto K., Hamanaka S., Morita I., Masaki H.
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kasawaki Medical School, Okayama, Japan
Aim. We measured the platelet count and platelet function in residual blood in the cardiopulmonary bypass (CPB) circuit after cpb and compared them with data before CPB operation.
Methods. The subjects included 34 cases of patients subjected to CPB surgery. The residual blood was concentrated by ultrafiltration after CPB, collected in the bag and the platelet count and platelet activity was measured. ADP 2, 5, 10 mM was used as agonists and measurement was made by turbidimetry.
Results. The mean value of the platelet count was 18.3±5.65¥104/mm3 before surgery and 17.2±8.39¥104/ mm3 in the residual blood, there is no difference. Concerning the platelet aggregation activity, the maximum aggregation rate decreased significantly with ADP 2 mM from 47.4±19.6% before surgery to 27.1±17.2% in the residual blood (p<0.01). Likewise, it decreased significantly with ADP 5 and 10 mM. The reduction rate of the platelet aggregation activity was higher in the group of not less than 100 minutes compared with the group of less than 100 minutes, but no significant difference was found.
Conclusion. Autotransfusing whole blood per se without the “cell saver” treatment is more advantageous to keep hemostasis function after surgery since many platelets having the aggregation activity exist in residual blood in the CPB circuit.