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Rivista di Chirurgia Cardiaca, Vascolare e Toracica

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The Journal of Cardiovascular Surgery 2003 October;44(5):605-9

lingua: Inglese

Helicobacter pylori seropositivity in patients with unstable angina

Pellicano R. 1, Mazzarello M. G. 2, Morelloni S. 3, Ferrari M. 2, Angelino P. 4, Berrutti M. 1, Torriglia A. M. 2, Rizzetto M. 1,5, Ponzetto A. 1,5

1 Depart­ment of ­Gastro-Hep­a­tology, Mol­in­ette Hos­pital, ­Turin, ­Italy
2 Clin­ical Labor­a­tory, ASL 22, ­Ovada (AL), ­Italy
3 Inten­sive Cor­o­nary ­Care ­Unit, ASL 22, Novi ­Ligure (AL), ­Italy
4 Car­di­ology, ­Rivoli Hos­pital, ­Turin, ­Italy
5 Depart­ment of ­Internal Med­i­cine, Uni­ver­sity of ­Turin, ­Turin, ­Italy

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Aim. The path­o­gen­esis of ­ischemic ­heart dis­eases has ­been cor­re­lated, on epi­dem­i­olog­ical and pathog­e­netic ­grounds, ­with infec­tions by ­viruses and bac­teria, ­including Helic­o­bacter ­pylori (H. ­pylori). The ­aims of ­this ­study ­were to inves­ti­gate the asso­ci­a­tion of ­unstable ­angina (UA) ­with ­anti-H. ­pylori ser­o­pos­i­tivity in a ­case-con­trol ­study and to ­search for the ­classic car­di­o­vas­cular ­risk fac­tors in ­both ­infected and unin­fected ­patients.
­Methods. We ­studied 32 con­sec­u­tive ­patients (20 ­males, 12 ­females), ­mean age 65 ­years (­range 42-89), ­with ­final diag­nosis of UA. A ­total of 64 sub­jects (40 ­males, 24 ­females, ­mean age 65 ­years, ­range 42-89) ­admitted to the Emer­gency ­Care ­Unit, age and sex-­matched, ­served as con­trols. The pres­ence of hyper­ten­sion, ­serum ­levels of cho­les­terol and glu­cose, ­plasma ­levels of ­fibrinogen, ­smoking ­habit and ­social ­class ­were inves­ti­gated in all ­patients. ­Cases and con­trols ­were inhab­i­tants of North­Western ­Italy, and had sim­ilar soci­oec­o­nomic ­status as ­based on ­working ­place and on instruc­tion ­level. H. ­pylori ser­o­prev­a­lence was ­assessed by the pres­ence of anti­bodies (IgG) ­against H. ­pylori by ­means of a com­mer­cial ­enzyme immu­no­sor­bent ­assay.
­Results. Anti­bodies to H. ­pylori ­were ­found in 26/32 (81%) of the ­patients and in 34/64 (53%) of the con­trols (p=0.007); the ­odds ­ratio was 3.82 (95% con­fi­dence ­interval 1.27 to 12.04). Clas­sical car­di­o­vas­cular ­risk fac­tors, ­such as ­socio-eco­nomic ­status, did not ­differ ­among ­patients ­with and ­without anti­bodies to H. ­pylori.
Con­clu­sion. ­Patients ­with ­unstable ­angina had a sig­nif­i­cantly ­higher ser­o­prev­a­lence of ­anti-H. ­pylori ­than the con­trol pop­u­la­tion. Clas­sical ­risk fac­tors for ­ischemic ­heart dis­ease, ­such as the indi­ca­tors of ­socio-eco­nomic ­status, ­were ­equally dis­trib­uted ­among ­infected or unin­fected ­patients ­with UA.

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