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THE JOURNAL OF CARDIOVASCULAR SURGERY

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The Journal of Cardiovascular Surgery 2003 February;44(1):125-9

lingua: Inglese

The importance of the time interval between diagnosis and operation in myasthenia gravis patients

Dural K., Yildirim E., Han S., Özisik K., Ulasan N., Saygin H., Sakinci Ü.

Depart­ment of Tho­racic Sur­gery Ankara ­Numune Edu­ca­tion and ­Research Hos­pital ­Ankara, ­Turkey


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Aim. Com­plete remis­sion ­rates in ­patients ­with myas­thenia ­gravis (MG) ­using anti­cho­line este­rases, immu­no­sup­pres­sive ­drugs, and med­ical ­therapy ­methods ­like plas­ma­pher­esis are low. ­Because ­high ­levels of com­plete remis­sion and advan­tages are ­reported ­after thy­mec­tomy ­this sur­gical ­method is ­widely ­used in ­patients ­with MG.
­Methods. The pre­op­er­a­tive ­status and the ­responses to thy­mec­tomy ­have ­been ­studied in 15 ­patients who had ­been diag­nosed as MG and under­went thy­mec­tomy in ­Ankara ­Numune Edu­ca­tion and ­Research Hos­pital.
­Results. ­Patients who under­went thy­mec­tomy ­have ­shown a ­high pro­por­tion of clin­ical improve­ment (73%). We ­could not estab­lish a ­direct rela­tion­ship ­between the ­results and the ­patients’ age, sex fea­tures and the path­o­log­ical char­ac­ter­is­tics of the exci­sional ­biopsy spec­i­mens. The ben­efit ­rates for ­patients who had a ­short ­period of ­time ­between diag­nosis and oper­a­tion (87.5%) ­were ­higher (91%).
Con­clu­sion. Thy­mec­tomy ­because of its ­high ben­efit ­rate is an advan­ta­geous ther­a­peutic ­tool. The ­chance of ben­e­fiting ­from thy­mec­tomy ­increases ­when the his­tory of MG is ­short and the ­stage of the dis­ease is ­early.

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