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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES CARDIAC SECTION
The Journal of Cardiovascular Surgery 2003 February;44(1):31-5
Elevated levels of s-100β correlate with neurocognitive outcome after cardiac surgery
Farsak B., Gunaydin S., Yorgancioglu C., Zorlutuna Y.
Department of Thoracic and Cardiovascular Surgery Bayindir Hospital, Ankara, Turkey
Aim. S-100β is a specific astroglial protein whose serum level increases after cerebral injury. The purpose of this study was to investigate the correlation between elevated levels of S-100β and the neurocognitive outcome after cardiac surgery.
Methods. Fifty consecutive patients undergoing elective coronary artery bypass grafting were studied. Serum S-100β levels were measured on induction of anaesthesia, at the 15th minute, at skin closure and on the 1st postoperative day. Neurocognitive outcome was evaluated by STAI-T and Zung tests preoperatively and by Mini-mental state examination every postoperative day until discharge. Neurocognitive tests and S-100β levels were correlated within the scope of risk factors by Pearson correlation.
Results. Serum S-100β was not detected preoperatively. Peak serum S-100β levels were reached at skin closure in 36 of 50 patients (72%). In 24 hours, serum S-100β disappeared in 25 patients but was still elevated in 11 (22%). A highly significant correlation was demonstrated between the duration of CPB and peak serum S-100β levels (r=0.91). There was a weak correlation between age and peak S-100β levels (r=0.62). Nine patients (18%) had a positive MMSE test which correlated well with persistent high serum S-100 levels (r=0.98).
Conclusion. Serum S-100β is a promising early biochemical marker for cerebral injury following cardiac surgery within a good correlation with the CPB time, age and especially with neurocognitive tests.