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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES THORACIC SECTION
The Journal of Cardiovascular Surgery 2002 October;43(5):729-34
Clinical significance of the preoperative serum-soluble intercellular adhesion molecule-1 in non-small cell lung cancer
Kamiyoshihara M. 1, Kawashima O. 2, Otani Y. 3, Morishita Y. 3
1 Department of Thoracic and Cardiovascular Surgery Maebashi Red Cross Hospital, Maebashi, Gunma, Japan
2 Department of Surgery National Sanatorium Nishigunma Hospital, Shibukawa, Gunma, Japan
3 Second Department of Surgery Gunma University School of Medicine, Maebashi, Gunma, Japan
Background. The serum-soluble intercellular adhesion molecule-1 (sICAM-1) is reported to correlate with both the metastatic potential and a poor prognosis. We analyzed the sICAM-1 concentrations and investigated whether or not the serum levels of these adhesion molecules in the peripheral venous blood could help predict the clinical staging in patients with NSCLC.
Methods. From January to December 1999, 66 patients (79.5%) underwent either a lobectomy or a pneumonectomy with a mediastinal lymph node dissection at the National Sanatorium Nishi-Gunma Hospital.
Results. The sICAM-1 concentration in the NSCLC patients was a mean value of 212.0±106.6 ng/ml. In contrast, the concentration of sICAM-1 in 20 healthy controls was a mean value of 117.9±64.1 ng/ml. In patients with NSCLC, the sICAM-1 concentrations were significantly higher than in the normal control group (p=0.002). In addition, the difference in the serum concentrations was significant between the patients with T1 and T2 disease (p=0.042), and N0 and N2 patients (p=0.042). No significant differences were observed in aging, smoking history, histological type, or pathological staging.
Conclusions. The sICAM-1 concentrations in lung cancer patients are thus suggested to play a role in staging, and may also serve as a useful indicator of advanced disease.