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ULTIMO FASCICOLOTHE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Periodicità: Bimestrale

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2002 Agosto;43(4):489-93

VASCULAR SECTION 

 ORIGINAL ARTICLES

Sialic acid is an indicator of inflammation due to cardiopulmonary bypass but not myocardial damage

Berkan Ö. 1, Göl M. K. 2, Günay L. 3, Sagaban M. 1

1 Izmir ­State Hos­pital, Car­di­o­vas­cular Sur­gery Clinic, ­Izmir, ­Turkey
2 Türkiye ­Yüksek ­Ihtisas Hos­pital, Car­di­o­vas­cular Sur­gery ­Clinic, ­Ankara, ­Turkey
3 Cum­hu­riyet Uni­ver­sity Med­ical ­Faculty Car­di­oth­o­racic Sur­gery Depart­ment, ­Sivas, ­Turkey

Back­ground. The aim of the ­present ­study was to inves­ti­gate ­whether ­serum ­sialic ­acid is asso­ciated ­with the inflam­ma­tory ­response of car­di­o­pul­mo­nary ­bypass (CPB) or not, ­since car­di­o­pul­mo­nary ­bypass is ­known to pro­duce a ­systemic inflam­ma­tory syn­drome.
­Methods. In 20 ­patients in ­whom elec­tive cor­o­nary ­bypass ­grafting was ­done, arte­rial and cor­o­nary ­sinus ­blood sam­pling was ­done simul­ta­ne­ously. The ­timing of sam­plings was 8-10 min­ ­after the insti­tu­tion of CPB, ­just ­before the appli­ca­tion of ­aortic ­clamping (T1) and 2 min ­after ­cross ­clamp ­removal (T2), ­when ­there was cor­o­nary cir­cu­la­tion, but no myo­car­dial acti­va­tion.
­Results. ­Sialic ­acid, CK-MB, lac­tate ­levels ­were sig­nif­i­cantly ­higher at T2 ­than ­those at T1 for ­both arte­rial and cor­o­nary ­sinus sam­ples. ­Increase at T2 ­time ­point for SA, CK-MB and ­lactic ­acid at cor­o­nary ­sinus ­were ­closely cor­re­lated ­with the ­systemic ­increase of ­these sub­stances ­also. Actu­ally, ­increase of ­systemic and cor­o­nary ­sinus CK-MB ­levels was ­also cor­re­lated ­with the dura­tion of ­aortic ­cross-­clamping and car­di­o­pul­mo­nary ­bypass. Prob­ably due to con­sump­tion, a neg­a­tive cor­re­la­tion ­with the ­decrease of ­fibrinogen at cor­o­nary ­sinus was ­found ­with the dura­tion of ­aortic ­cross-­clamping.
Con­clu­sions. Our ­study ­showed a ­strong and con­sis­tent asso­ci­a­tion ­between ­serum SA con­cen­tra­tion and the inflam­ma­tory pro­cess. ­There are pre­vious ­reports ­that ­show ­sialic ­acid ­levels asso­ciated ­with ­ischemic ­insult to myo­car­dium. We are ­able to ­show ­that ­serum TSA cor­re­lates ­well ­with ­some of the ­acute ­phase pro­teins but ­this was not ­true ­with ­ischemic ­markers ­after car­di­o­plegic ­arrest.

lingua: Inglese


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