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THE JOURNAL OF CARDIOVASCULAR SURGERY
Rivista di Chirurgia Cardiaca, Vascolare e Toracica
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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ORIGINAL ARTICLES THORACIC SECTION
The Journal of Cardiovascular Surgery 2002 April;43(2):281-6
Prosthetic reconstruction of the trachea in rabbit
Abdülcemal Isik Ü., Seren E., Kaklikkaya I. *, Bektas D., Imamoglu M., Muhtar H., Civelek S. **
From the Department of Otolaryngology
*and Department of Thoracic and Cardiovascular Surgery Karadeniz Technical University, School of Medicine,
**State Hospital, Department of Otolaryngology, Rize, Turkey
Background. Various tracheal reconstruction techniques have been developed for stenosis. Different types of grafts, flaps and synthetic materials have been used for reconstruction of the defect when primary anastomosis was unsuccessful or not indicated. The mentioned reconstruction methods have limited success. Polytetrafluoro-ethylene (PTFE) prosthesis is a microporous polymer and has been applied for implantation on a wide range. It is also appropriate for tracheal reconstruction.
Methods. In the present study, segmental defects were created in 12 New Zealand rabbits. The rabbits were divided into 2 subgroups; the first group was applied an end-to-end anastomosis whilst the second a PTFE prosthesis. After 2 months, these applications were compared clinically, endoscopically and histopathologically to each other.
Results. Necrosis and extrusion were not observed in the rabbits with PTFE applications. After 1 month, the tracheal stenosis was found on endoscopic examination in 5 animals in the first group and 2 animals in the second group. While in longer defects, end-to-end anastomosis causes tracheal tension, PTFE applications have been well tolerated.
Conclusions. It is concluded that PTFE prosthesis is a suitable alternative method in reconstruction of circumferential tracheal defects.