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Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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ORIGINAL ARTICLES  VASCULAR SECTION


The Journal of Cardiovascular Surgery 2002 Febbraio;43(1):77-82

lingua: Inglese

Oxygen free radicals in abdominal aortic surgery. An experimental study

Dimakakos P. B., Kotsis T., Kondi-Pafiti A. *, Katsenis K., Doufas A. **, Chondros K. ***, Kouskouni E. ***

From the Depart­ment of Vas­cular Sur­gery, 2nd Sur­gical ­Clinic
*Depart­ment of ­Pathology
**Depart­ment of Anes­the­sio­logy
***Depart­ment of Micro­bi­ology
Uni­ver­sity of ­Athens Are­teion Hos­pital, ­Athens, ­Greece


PDF  ESTRATTI


Back­ground. In ­aortic recon­struc­tion, intes­tinal and mus­cular ­ischaemia in the ­lower ­limbs ­occurs ­during ­cross-­clamping of the ­aorta. ­After res­to­ra­tion of ­blood ­flow, reac­tive ­oxygen inter­me­di­ates may ­lead to ­systemic ­injury to ­local or ­remote ­organs. In ­this ­study we inves­ti­gated the use­ful­ness of a ­shunt and ­vitamin E admin­is­tra­tion ­against the oxi­dant ­load gen­er­ated in ­ischaemia-reper­fu­sion ­phases.
­Methods. In ­three ­groups of ­pigs (n=16) ­aortic recon­struc­tion was sim­u­lated. In ­Group A (n=5) ­clamping of the infra­renal ­aorta was per­formed for 2 ­hours. In ­Group B (n=6), ­during ­aortic ­cross-­clamping, a ­shunt was ­used to ­give ­flow to the infe­rior mes­en­teric and ­internal ­iliac ­arteries. In ­Group C (n=5) ­vitamin E was admin­is­tered ­before ­aortic ­cross-­clamping. In all ­groups we eval­u­ated sig­moid his­tology ­after reper­fu­sion, ­while the oxi­dant ­load was esti­mated by meas­uring super­oxide dis­mu­tase (SOD) ­activity in ­blood sam­ples ­from ­portal and jug­ular ­vein.
­Results. His­tology of the sig­moid ­revealed ­increased post­is­chaemic inju­ries in ­Group A, ­while the pro­tec­tive ­effect of ­shunt and ­vitamin E was ­apparent in ­Group B and C, respec­tively. SOD ­activity was min­i­mized in ­Group C.
Con­clu­sions. ­Vitamin E pro­tected the sig­moid ­from post­is­chaemic ­injury and is respon­sible for the ­decreased ­levels of SOD ­activity.

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