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THE JOURNAL OF CARDIOVASCULAR SURGERY

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The Journal of Cardiovascular Surgery 2001 Ottobre;42(5):667-73

lingua: Inglese

Effects of fibronectin bonding on healing of high porosity expanded polytetrafluoroethylene grafts in pigs

Nishibe T. 1,2, O’Donnel S. 2, Pikoulis E. 2, Rich N. 2, Okuda Y. 3, Kumada T. 4, Kudo F. 1, Tanabe T. 1, Yasuda K. 1

From ­the
1 Department of Cardiovascular Surgery Hokkaido University School of Medicine, Sapporo, Japan
2 Department of Surgery Uniformed Services University of ­the Health Sciences Bethesda, ­USA
3 Sumitomo Electric Industries, Co. Ltd., Osaka, Japan
4 Dai-­ichi Pharmaceutical Company Ltd., Tokyo, Japan


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Background. We devel­oped a ­new fibro­nec­tin bond­ing to expand­ed poly­tet­ra­flu­o­roe­thy­lene (ePTFE) ­and pre­vi­ous­ly report­ed ­that, in a ­dog carot­id ­implant mod­el, fibro­nec­tin bond­ing ­improves ­graft heal­ing in ­high poros­ity ePTFE ­grafts. The pur­pose of ­this ­study ­was to fur­ther inves­ti­gate ­the ­effect of ­the fibro­nec­tin bond­ing on ­graft heal­ing in a ­pig carot­id ­implant mod­el.
Methods. Fifteen ­pigs ­received a ­high poros­ity ePTFE ­graft treat­ed ­with ­the fibro­nec­tin bond­ing (fibro­nec­tin-bond­ed ­graft) on ­one ­side ­and an untreat­ed ­graft (­non-bond­ed ­graft) on ­the con­tra­lat­er­al ­side. The ­grafts ­were explant­ed at inter­vals of 3 ­and 6 ­weeks ­and sub­ject­ed to his­to­log­i­cal stud­ies.
Results. At 3 ­weeks, ­the neo­in­ti­ma of fibro­nec­tin-bond­ed ­grafts ­was bet­ter orga­nized ­than ­that of ­non-bond­ed ­grafts. At 6 ­weeks, ­the mor­pho­log­ic fea­tures of ­the neo­in­ti­ma ­were ­the ­same in fibro­nec­tin-bond­ed ­and ­non-bond­ed ­grafts. The neo­in­ti­ma ­was com­plete­ly orga­nized.
Conclusions. Together ­with ­the pre­vi­ous ­results ­with ­the ­dog mod­el, fibro­nec­tin bond­ing ­could be expect­ed to ­improve heal­ing of ­the ­high poros­ity ePTFE ­grafts in ­humans.

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