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FASCICOLI E ARTICOLI   I PIÙ LETTI   eTOC

ULTIMO FASCICOLOTHE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica

Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,632

Periodicità: Bimestrale

ISSN 0021-9509

Online ISSN 1827-191X

 

The Journal of Cardiovascular Surgery 2001 Ottobre;42(5):667-73

VASCULAR SECTION 

 ORIGINAL ARTICLES

Effects of fibronectin bonding on healing of high porosity expanded polytetrafluoroethylene grafts in pigs

Nishibe T. 1,2, O’Donnel S. 2, Pikoulis E. 2, Rich N. 2, Okuda Y. 3, Kumada T. 4, Kudo F. 1, Tanabe T. 1, Yasuda K. 1

From ­the
1 Department of Cardiovascular Surgery Hokkaido University School of Medicine, Sapporo, Japan
2 Department of Surgery Uniformed Services University of ­the Health Sciences Bethesda, ­USA
3 Sumitomo Electric Industries, Co. Ltd., Osaka, Japan
4 Dai-­ichi Pharmaceutical Company Ltd., Tokyo, Japan

Background. We devel­oped a ­new fibro­nec­tin bond­ing to expand­ed poly­tet­ra­flu­o­roe­thy­lene (ePTFE) ­and pre­vi­ous­ly report­ed ­that, in a ­dog carot­id ­implant mod­el, fibro­nec­tin bond­ing ­improves ­graft heal­ing in ­high poros­ity ePTFE ­grafts. The pur­pose of ­this ­study ­was to fur­ther inves­ti­gate ­the ­effect of ­the fibro­nec­tin bond­ing on ­graft heal­ing in a ­pig carot­id ­implant mod­el.
Methods. Fifteen ­pigs ­received a ­high poros­ity ePTFE ­graft treat­ed ­with ­the fibro­nec­tin bond­ing (fibro­nec­tin-bond­ed ­graft) on ­one ­side ­and an untreat­ed ­graft (­non-bond­ed ­graft) on ­the con­tra­lat­er­al ­side. The ­grafts ­were explant­ed at inter­vals of 3 ­and 6 ­weeks ­and sub­ject­ed to his­to­log­i­cal stud­ies.
Results. At 3 ­weeks, ­the neo­in­ti­ma of fibro­nec­tin-bond­ed ­grafts ­was bet­ter orga­nized ­than ­that of ­non-bond­ed ­grafts. At 6 ­weeks, ­the mor­pho­log­ic fea­tures of ­the neo­in­ti­ma ­were ­the ­same in fibro­nec­tin-bond­ed ­and ­non-bond­ed ­grafts. The neo­in­ti­ma ­was com­plete­ly orga­nized.
Conclusions. Together ­with ­the pre­vi­ous ­results ­with ­the ­dog mod­el, fibro­nec­tin bond­ing ­could be expect­ed to ­improve heal­ing of ­the ­high poros­ity ePTFE ­grafts in ­humans.

lingua: Inglese


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