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THE JOURNAL OF CARDIOVASCULAR SURGERY

Rivista di Chirurgia Cardiaca, Vascolare e Toracica


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The Journal of Cardiovascular Surgery 2001 June;42(3):323-31

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Differences in prolonged ischemia lenght using ischemic preconditioning in the rabbit heart. Tolerable limitation time for surgically induced myocardial ischemia during normothermic cardiac operation

Uematsu M., Okada M.

From the Department of Surgery Division II, Kobe University of Medicine, Kobe, Japan


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Background. To deter­mine the ­effect of the tol­er­able lim­i­ta­tion ­time of pro­longed ische­mia ­after ischem­ic pre­con­di­tion­ing on ­postischem­ic func­tion­al recov­ery and ­infarct ­size reduc­tion in the rab­bit ­heart.
Methods. White rab­bits (n=30) ­were ­used for Langendorff per­fu­sion. Control ­hearts ­were per­fused at 37°C for 180 min; 30 min glo­bal ischemia ­hearts (30GI) ­received 30 min glo­bal ische­mia and 120 min reper­fu­sion; IPC+30GI ­hearts ­received 5 min ­zero ­flow glo­bal ische­mia and 5 min reper­fu­sion ­prior to 30 min glo­bal ische­mia; 20 min glo­bal ischemia ­hearts (20GI) ­received 20 min glo­bal ische­mia and 120 min reper­fu­sion; IPC+20GI ­hearts ­received 5 min ­zero ­flow glo­bal ische­mia and 5 min reper­fu­sion ­prior to 20 min glo­bal ische­mia.
Results. Infarct ­size in the 30GI ­hearts was 33.5±4.0% and 1.7±0.5% in the con­trol ­hearts. The 20GI ­hearts and IPC+30GI ­hearts ­decreased ­infarct ­size, as com­pared ­with the 30GI ­hearts (13.0±1.8% and 16.6±1.7%, respec­tive­ly; p<0.001, 20GI vs 30GI; p<0.01, IPC+30GI vs 30GI; p>0.05, 20GI vs IPC+30GI) but did not ­enhance ­postischem­ic func­tion­al recov­ery. The IPC+20GI ­hearts (3.5±0.6%) sig­nif­i­cant­ly ­decreased ­infarct ­size as com­pared ­with the 20GI ­hearts (p<0.05, IPC+20GI vs 20GI), and ­there was no sig­nif­i­cant dif­fer­ence ­between the IPC+20GI and the con­trol ­hearts (p>0.05), but the IPC+20GI ­hearts did not ­enhance ­postischem­ic func­tion­al recov­ery.
Conclusions. A 20 min ische­mia may be the tol­er­able limit­a­ta­tion ­time of pro­longed ische­mia ­after ischem­ic pre­con­di­tion­ing in an iso­lat­ed rab­bit ­heart mod­el.

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